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    GPR153 G protein-coupled receptor 153 [ Homo sapiens (human) ]

    Gene ID: 387509, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GPR153provided by HGNC
    Official Full Name
    G protein-coupled receptor 153provided by HGNC
    Primary source
    HGNC:HGNC:23618
    See related
    Ensembl:ENSG00000158292 MIM:614269; AllianceGenome:HGNC:23618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR1
    Summary
    This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]
    Expression
    Broad expression in colon (RPKM 6.6), fat (RPKM 4.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6247353..6261098, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (5772997..5786742, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6307413..6321158, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6296257-6297229 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6299873-6300619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6304377-6304934 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6305171-6305522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 145 Neighboring gene ICMT divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6309743-6310284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 150 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6329739-6330330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6330331-6330921 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6333683-6333849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6335064-6335654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6339577-6340442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6340686-6341235 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 76 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:6361272-6362471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6396158-6396892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6397980-6398642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6398643-6399303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6399966-6400626 Neighboring gene Sharpr-MPRA regulatory region 5603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6417160-6418127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 79 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 80 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6424607-6425106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6427779-6428559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6434479-6434978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6445825-6446810 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:6453176-6453687 and GRCh37_chr1:6453688-6454200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:6454201-6454711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6455464-6455988 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:6474153-6474654 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:6474655-6475154 Neighboring gene hes family bHLH transcription factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system. Krishnan A, et al. J Exp Biol, 2015 Feb 15. PMID 25696819
    2. De novo variants in sporadic cases of childhood onset schizophrenia. Ambalavanan A, et al. Eur J Hum Genet, 2016 Jun. PMID 26508570, Free PMC Article
    3. The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus. Sreedharan S, et al. FEBS J, 2011 Dec. PMID 21981325
    4. Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors. Kakarala KK, et al. Mol Phylogenet Evol, 2014 May. PMID 24503482
    5. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Gloriam DE, et al. Biochim Biophys Acta, 2005 Apr 15. PMID 15777626

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp762B2210

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 153
    Names
    G-protein coupled receptor PGR1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053044.1 RefSeqGene

      Range
      4893..18638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_207370.4 → NP_997253.2  probable G-protein coupled receptor 153

      See identical proteins and their annotated locations for NP_997253.2

      Status: REVIEWED

      Source sequence(s)
      AL031847, BC068275, BQ575651
      Consensus CDS
      CCDS64.1
      UniProtKB/Swiss-Prot
      Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
      UniProtKB/TrEMBL
      A0A0I9QQ03
      Related
      ENSP00000367125.2, ENST00000377893.3
      Conserved Domains (1) summary
      pfam00001
      Location:29 → 219
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      6247353..6261098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541434.4 → XP_011539736.1  probable G-protein coupled receptor 153 isoform X1

      See identical proteins and their annotated locations for XP_011539736.1

      UniProtKB/Swiss-Prot
      Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
      UniProtKB/TrEMBL
      A0A0I9QQ03
      Conserved Domains (1) summary
      pfam00001
      Location:29 → 219
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_017001250.2 → XP_016856739.1  probable G-protein coupled receptor 153 isoform X1

      UniProtKB/Swiss-Prot
      Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
      UniProtKB/TrEMBL
      A0A0I9QQ03
      Conserved Domains (1) summary
      pfam00001
      Location:29 → 219
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      5772997..5786742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336486.1 → XP_054192461.1  probable G-protein coupled receptor 153 isoform X1

      UniProtKB/Swiss-Prot
      Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
      UniProtKB/TrEMBL
      A0A0I9QQ03

    2. XM_054336485.1 → XP_054192460.1  probable G-protein coupled receptor 153 isoform X1

      UniProtKB/Swiss-Prot
      Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
      UniProtKB/TrEMBL
      A0A0I9QQ03
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NV75.2 GenPept UniProtKB/Swiss-Prot:Q6NV75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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