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    Crebrf CREB3 regulatory factor [ Mus musculus (house mouse) ]

    Gene ID: 77128, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Crebrfprovided by MGI
    Official Full Name
    CREB3 regulatory factorprovided by MGI
    Primary source
    MGI:MGI:1924378
    See related
    Ensembl:ENSMUSG00000048249 AllianceGenome:MGI:1924378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LRF; A930001N09Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within maternal behavior; negative regulation of glucocorticoid mediated signaling pathway; and positive regulation of prolactin signaling pathway. Located in nuclear body. Is expressed in blastocyst; early embryo; polar body; and uterus. Orthologous to human CREBRF (CREB3 regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.4), cerebellum adult (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crebrf in Genome Data Viewer
    Location:
    17 A3.3; 17 13.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26918716..26995611)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26715594..26776637)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1 Neighboring gene predicted gene, 41553 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit E Neighboring gene STARR-positive B cell enhancer ABC_E3193 Neighboring gene STARR-positive B cell enhancer ABC_E2474 Neighboring gene STARR-positive B cell enhancer ABC_E8660 Neighboring gene BCL2/adenovirus E1B interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_42133 Neighboring gene STARR-seq mESC enhancer starr_42134 Neighboring gene NK2 homeobox 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Limited Metabolic Effect of the CREBRF(R457Q) Obesity Variant in Mice. Metcalfe LK, et al. Cells, 2022 Jan 31. PMID 35159305, Free PMC Article
    2. Molecular characterization of mouse CREB3 regulatory factor in Neuro2a cells. Oh-Hashi K, et al. Mol Biol Rep, 2021 Jul. PMID 34275032
    3. Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating Glucocorticoids in Male and Female Mice. Frahm KA, et al. Endocrinology, 2020 Nov 1. PMID 32901804, Free PMC Article
    4. Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice. Yang Y, et al. J Reprod Dev, 2013. PMID 23400243, Free PMC Article
    5. A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. Kanshana JS, et al. PLoS One, 2021. PMID 34520472, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Limited Metabolic Effect of the CREBRF(R457Q) Obesity Variant in Mice.
      Title: Limited Metabolic Effect of the CREBRF(R457Q) Obesity Variant in Mice.
    2. Molecular characterization of mouse CREB3 regulatory factor in Neuro2a cells.
      Title: Molecular characterization of mouse CREB3 regulatory factor in Neuro2a cells.
    3. A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.
      Title: A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.
    4. Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating Glucocorticoids in Male and Female Mice.
      Title: Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating Glucocorticoids in Male and Female Mice.
    5. LRF has a role in the process of implantation in uteri and development of preimplantation embryos in mice
      Title: Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice.
    6. postulate that LRF plays a critical role in the attenuation of the HPA axis through repression of glucocorticoid stress signaling during parturition and the postpartum period
      Title: Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within maternal behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within maternal behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of glucocorticoid mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of glucocorticoid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of prolactin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CREB3 regulatory factor
    Names
    UPF0474 protein C5orf41 homolog
    luman recruitment factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029870.2 → NP_084146.1  CREB3 regulatory factor

      See identical proteins and their annotated locations for NP_084146.1

      Status: VALIDATED

      Source sequence(s)
      AK030092, CT025550
      Consensus CDS
      CCDS37516.1
      UniProtKB/Swiss-Prot
      B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
      UniProtKB/TrEMBL
      B8JJI2
      Related
      ENSMUSP00000059102.8, ENSMUST00000062519.14
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26918716..26995611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160833.1 → XP_036016726.1  CREB3 regulatory factor isoform X1

      UniProtKB/Swiss-Prot
      B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    2. XM_011246717.4 → XP_011245019.2  CREB3 regulatory factor isoform X1

      UniProtKB/Swiss-Prot
      B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    3. XM_036160838.1 → XP_036016731.1  CREB3 regulatory factor isoform X3

      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:484 → 522
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    4. XM_017317723.3 → XP_017173212.1  CREB3 regulatory factor isoform X1

      UniProtKB/Swiss-Prot
      B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    5. XM_036160837.1 → XP_036016730.1  CREB3 regulatory factor isoform X2

      UniProtKB/TrEMBL
      B8JJI2
      Related
      ENSMUSP00000114274.2, ENSMUST00000142539.8
      Conserved Domains (1) summary
      cd14809
      Location:518 → 556
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    6. XM_036160836.1 → XP_036016729.1  CREB3 regulatory factor isoform X1

      UniProtKB/Swiss-Prot
      B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    7. XM_036160839.1 → XP_036016732.1  CREB3 regulatory factor isoform X3

      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:484 → 522
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    8. XM_036160834.1 → XP_036016727.1  CREB3 regulatory factor isoform X1

      UniProtKB/Swiss-Prot
      B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    9. XM_036160835.1 → XP_036016728.1  CREB3 regulatory factor isoform X1

      UniProtKB/Swiss-Prot
      B8JJI1, Q14DI2, Q8C8N7, Q8CDG5, Q9CTQ7
      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:526 → 564
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    10. XM_036160840.1 → XP_036016733.1  CREB3 regulatory factor isoform X4

      UniProtKB/TrEMBL
      B8JJI2
      Conserved Domains (1) summary
      cd14809
      Location:478 → 516
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDG5.1 GenPept UniProtKB/Swiss-Prot:Q8CDG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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