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    Klhdc10 kelch domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 76788, updated on 12-May-2024

    Summary

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    Official Symbol
    Klhdc10provided by MGI
    Official Full Name
    kelch domain containing 10provided by MGI
    Primary source
    MGI:MGI:1924038
    See related
    Ensembl:ENSMUSG00000029775 AllianceGenome:MGI:1924038
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0265; 2410127E18Rik
    Summary
    Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in positive regulation of stress-activated MAPK cascade and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human KLHDC10 (kelch domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 31.1), whole brain E14.5 (RPKM 31.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhdc10 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30401516..30455178)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30401517..30455179)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700095J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E4817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30290290-30290473 Neighboring gene STARR-seq mESC enhancer starr_15465 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30307653-30307954 Neighboring gene zinc finger, C3HC type 1 Neighboring gene STARR-positive B cell enhancer ABC_E6420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30351601-30351833 Neighboring gene RIKEN cDNA 1700012C14 gene Neighboring gene transmembrane protein 209 Neighboring gene STARR-seq mESC enhancer starr_15468

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation. Yamaguchi N, et al. PLoS One, 2016. PMID 27631783, Free PMC Article
    2. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett, 2000 Apr 28. PMID 10788617
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0265

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kelch domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311087.1 → NP_001298016.1  kelch domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001298016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK085116, BC056496, CJ134796
      Consensus CDS
      CCDS80509.1
      UniProtKB/Swiss-Prot
      Q6PAR0
      Related
      ENSMUSP00000064594.7, ENSMUST00000068240.13
      Conserved Domains (4) summary
      PLN02153
      Location:107 → 270
      PLN02153; epithiospecifier protein
      PRK14131
      Location:56 → 139
      PRK14131; N-acetylneuraminate epimerase
      sd00038
      Location:176 → 224
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:283 → 329
      Kelch_1; Kelch motif

    2. NM_029742.3 → NP_084018.1  kelch domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_084018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC056496, BC060132, CJ134796
      Consensus CDS
      CCDS19971.1
      UniProtKB/Swiss-Prot
      Q6A095, Q6PAR0, Q8BH94, Q8BPK7, Q8C3Q4, Q8C7G4, Q9CWF4
      Related
      ENSMUSP00000069669.7, ENSMUST00000068259.10
      Conserved Domains (4) summary
      PLN02153
      Location:136 → 299
      PLN02153; epithiospecifier protein
      PRK14131
      Location:85 → 168
      PRK14131; N-acetylneuraminate epimerase
      sd00038
      Location:205 → 253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:312 → 358
      Kelch_1; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30401516..30455178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255666.1 → XP_030111526.1  kelch domain-containing protein 10 isoform X2

      Conserved Domains (2) summary
      PLN02153
      Location:40 → 201
      PLN02153; epithiospecifier protein
      sd00038
      Location:54 → 100
      Kelch; KELCH repeat [structural motif]

    2. XM_017321829.2 → XP_017177318.1  kelch domain-containing protein 10 isoform X1

      Conserved Domains (4) summary
      PLN02153
      Location:132 → 295
      PLN02153; epithiospecifier protein
      PRK14131
      Location:81 → 164
      PRK14131; N-acetylneuraminate epimerase
      sd00038
      Location:201 → 249
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:308 → 354
      Kelch_1; Kelch motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PAR0.1 GenPept UniProtKB/Swiss-Prot:Q6PAR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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