Slc6a14 solute carrier family 6 (neurotransmitter transporter), member 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc6a14provided by MGI
Official Full Name: solute carrier family 6 (neurotransmitter transporter), member 14provided by MGI
Primary source: MGI:MGI:1890216
See related: Ensembl:ENSMUSG00000031089 AllianceGenome:MGI:1890216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATB0plus; CATB0plus; 1110007A17Rik; 9030613J17Rik
Summary: Predicted to enable alanine transmembrane transporter activity and amine transmembrane transporter activity. Predicted to be involved in amino acid transport; response to toxic substance; and sodium ion transmembrane transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in brush border membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SLC6A14 (solute carrier family 6 member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 6.4), lung adult (RPKM 2.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: X 16.78 cM; X A2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (21581139..21608597)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (21714900..21742358)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer.
Title: Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer.
SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling.
Title: SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling.
The authors found that disruption of Slc6a14 worsened the intestinal fluid secretion defect, characteristic of Cystic Fibrosis-associated meconium ileus mice.
Title: SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion.
These studies demonstrate that SLC6A14 is critical for the maintenance of amino acid nutrition and optimal mammalian target of rapamycin (mTOR) signalling in ER+ breast cancer
Title: Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Markers

Slc6a14 (e-PCR), detects polymorphism
- UniSTS:546020

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (R)-carnitine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables (R)-carnitine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables (R)-carnitine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables aromatic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables beta-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables branched-chain amino acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables branched-chain amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables neutral, basic amino acid:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral, basic amino acid:sodium:chloride symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in (R)-carnitine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in (R)-carnitine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in (R)-carnitine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in alanine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amine transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in amino acid import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in beta-alanine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in beta-alanine transport	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Names: amino acid transporter ATB0+; colonic system B0+ amino acid transporter CATB0+; solute carrier family 6 member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020049.4 → NP_064433.3 sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

See identical proteins and their annotated locations for NP_064433.3

Status: VALIDATED

Source sequence(s)

AL807250, BC129908

Consensus CDS

CCDS30051.1

UniProtKB/Swiss-Prot

Q91Y60, Q9D317, Q9JMA9, Q9R183

UniProtKB/TrEMBL

A1L359

Related

ENSMUSP00000033414.8, ENSMUST00000033414.8

Conserved Domains (1) summary

cl00456
Location:36 → 637

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain