DKK1 dickkopf WNT signaling pathway inhibitor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DKK1provided by HGNC
Official Full Name: dickkopf WNT signaling pathway inhibitor 1provided by HGNC
Primary source: HGNC:HGNC:2891
See related: Ensembl:ENSG00000107984 MIM:605189; AllianceGenome:HGNC:2891
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SK; DKK-1
Summary: This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
Expression: Biased expression in placenta (RPKM 39.1), urinary bladder (RPKM 8.2) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q21.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (52314281..52317657)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (53160859..53164235)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (54074041..54077417)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of miR-590-3p/DKK1 Axis on the Progression of Wilms' Tumour.
Title: Effect of miR-590-3p/DKK1 Axis on the Progression of Wilms' Tumour.
Effects of Dickkopf-1 (DKK-1) on Prostate Cancer Growth and Bone Metastasis.
Title: Effects of Dickkopf-1 (DKK-1) on Prostate Cancer Growth and Bone Metastasis.
Close negative correlation of local and circulating Dickkopf-1 and Sclerostin levels during human fracture healing.
Title: Close negative correlation of local and circulating Dickkopf-1 and Sclerostin levels during human fracture healing.
Involvement of DKK1 secreted from adipose-derived stem cells in alopecia areata.
Title: Involvement of DKK1 secreted from adipose-derived stem cells in alopecia areata.
Dickkopf-1 is an immune infiltration-related prognostic biomarker of head and neck squamous cell carcinoma.
Title: Dickkopf-1 is an immune infiltration-related prognostic biomarker of head and neck squamous cell carcinoma.
Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis.
Title: Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis.
Circ_0036490 and DKK1 competitively bind miR-29a to promote lipopolysaccharides-induced human gingival fibroblasts injury.
Title: Circ_0036490 and DKK1 competitively bind miR-29a to promote lipopolysaccharides-induced human gingival fibroblasts injury.
DKK-1 and Its Influences on Bone Destruction: A Comparative Study in Collagen-Induced Arthritis Mice and Rheumatoid Arthritis Patients.
Title: DKK-1 and Its Influences on Bone Destruction: A Comparative Study in Collagen-Induced Arthritis Mice and Rheumatoid Arthritis Patients.
Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1.
Title: Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1.
DKK-1 in psoriatic arthritis: Correlation with disease activity and enthesopathy.
Title: DKK-1 in psoriatic arthritis: Correlation with disease activity and enthesopathy.

Submit: New GeneRIF Correction See all GeneRIFs (470)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of chronic periodontitis in a general German population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Several common variants modulate heart rate, PR interval and QRS duration. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of dickkopf-1 in primary human osteoblasts	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables co-receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables co-receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables low-density lipoprotein particle receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway involved in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic limb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoderm formation	IEA Inferred from Electronic Annotation more info
involved_in face morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
involved_in hair follicle development	IEA Inferred from Electronic Annotation more info
involved_in heart induction	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart valve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning or memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in limb development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesoderm formation	IEA Inferred from Electronic Annotation more info
involved_in motor learning	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cardiac muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mesodermal cell fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ossification	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Wnt signaling pathway, calcium modulating pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of midbrain dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopaminergic neuron differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of endodermal cell fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuron apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in synapse pruning	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome membrane	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dickkopf-related protein 1

Names: dickkopf 1 homolog; dickkopf-1 like; dickkopf-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.