Rab1a RAB1A, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab1aprovided by MGI
Official Full Name: RAB1A, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:97842
See related: Ensembl:ENSMUSG00000020149 AllianceGenome:MGI:97842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gtbp; Rab1; Ypt1; Rab-1; mKIAA3012
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in cell migration; melanosome transport; and substrate adhesion-dependent cell spreading. Located in Golgi apparatus and melanosome. Is expressed in several structures, including diaphragm and genitourinary system. Used to study dilated cardiomyopathy. Orthologous to human RAB1A (RAB1A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 75.8), liver E18 (RPKM 58.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.1; 11 12.92 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (20151412..20176856)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (20201412..20226856)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A.
Title: Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A.
Knockdown of Rab1A protein represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of the mTOR/p70S6K pathway.
Title: Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway.
this study shows that Rab1 is required for NLRP3 inflammasome activation and inflammatory lung injury
Title: The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.
clear effect of subcutaneous zoledronic acid administration in vivo on the prenylation of Rab1A, Rab5B, Rab7A and Rab14 in mouse peritoneal macrophages, confirming that systemic treatment with bisphosphonate drug can inhibit prenylation in myeloid cells in vivo outside the skeleton.
Title: A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton.
Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP
Title: Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP.
These data indicate that AMPylation of Rab1 is an effective strategy to maintain this GTPase on the Legionella-containing vacuole membrane.
Title: AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila.
Rab1A is the first crucial component of the anterograde melanosome transport machinery to be identified in mammalian skin melanocytes.
Title: Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes.
Acute expression of Rab1 and Rab3d DN constructs partially alleviated this negative feedback mechanism and resulted in impaired ER to Golgi trafficking of procollagen.
Title: Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts.
Legionella pneumophila SidD catalyzed AMP release from Rab1, generating de-AMPylated Rab1 accessible for inactivation by LepB; identified SidD as missing link connecting processes of early Rab1 accumulation and subsequent removal during infection
Title: De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila.
Results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts via a specific downstream effector pathway.
Title: Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB210615 (e-PCR)
- UniSTS:208644

WI-13176 (e-PCR)
- UniSTS:21297

D11Mit306 (e-PCR), detects polymorphism
- UniSTS:126517

MARC_33894-33895:1054217168:1 (e-PCR)
- UniSTS:466818

Rab1 (e-PCR), detects polymorphism
- UniSTS:527512

Rab1 (e-PCR), detects polymorphism
- UniSTS:144309

D11Hjk8 (e-PCR), detects polymorphism
- UniSTS:141752

Y00094 (e-PCR)
- UniSTS:125905

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in virion assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in melanosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-1A

Names: RAB1, member RAS oncogene family; YPT1-related protein; ras-related YPT1 protein

NP_033022.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.