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    Pmf1 polyamine-modulated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 67037, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pmf1provided by MGI
    Official Full Name
    polyamine-modulated factor 1provided by MGI
    Primary source
    MGI:MGI:1914287
    See related
    Ensembl:ENSMUSG00000028066 AllianceGenome:MGI:1914287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600009M07Rik
    Summary
    Predicted to enable leucine zipper domain binding activity and transcription coactivator activity. Predicted to be involved in chromosome segregation. Predicted to act upstream of or within cell division. Predicted to be located in Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of nuclear MIS12/MIND complex. Is expressed in several structures, including central nervous system; extraembryonic component; placenta; retina; and thymus. Human ortholog(s) of this gene implicated in bladder carcinoma and urinary bladder cancer. Orthologous to several human genes including PMF1-BGLAP (PMF1-BGLAP readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 35.3), ovary adult (RPKM 29.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 38.82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88301445..88317752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88394138..88410445, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 6-like Neighboring gene bone gamma carboxyglutamate protein Neighboring gene solute carrier family 25, member 44 Neighboring gene STARR-positive B cell enhancer ABC_E2076 Neighboring gene 60S ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor. Wang Y, et al. Biochem J, 2001 Oct 15. PMID 11583586, Free PMC Article
    2. Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene. Stephenson AH, et al. Life Sci, 2006 Aug 22. PMID 16647090
    3. Transcriptomic analysis of polyamine-related genes and polyamine levels in placenta, yolk sac and fetus during the second half of mouse pregnancy. Lopez-Garcia C, et al. Placenta, 2009 Mar. PMID 19131104
    4. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
    5. The KMN protein network--chief conductors of the kinetochore orchestra. Varma D, et al. J Cell Sci, 2012 Dec 15. PMID 23418356, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. formation of the Nrf-2/PMF-1 complex is involved in transcriptional regulation of 4E-BP1
      Title: Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables leucine zipper domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MIS12/MIND type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in spindle pole NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polyamine-modulated factor 1
    Names
    PMF-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310605.2 → NP_001297534.1  polyamine-modulated factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001297534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC102388
      Consensus CDS
      CCDS79942.1
      UniProtKB/Swiss-Prot
      Q9CPV5
      Related
      ENSMUSP00000141696.2, ENSMUST00000193338.6
      Conserved Domains (1) summary
      pfam03980
      Location:56 → 97
      Nnf1; Nnf1

    2. NM_025928.5 → NP_080204.1  polyamine-modulated factor 1 isoform 1

      See identical proteins and their annotated locations for NP_080204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102388
      Consensus CDS
      CCDS38481.1
      UniProtKB/Swiss-Prot
      Q3UCB8, Q8K237, Q924B3, Q9CPV5, Q9D6E2
      UniProtKB/TrEMBL
      Q8BVG3
      Related
      ENSMUSP00000062420.8, ENSMUST00000056370.13
      Conserved Domains (1) summary
      pfam03980
      Location:68 → 166
      Nnf1; Nnf1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88301445..88317752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240202.3 → XP_011238504.1  polyamine-modulated factor 1 isoform X1

      UniProtKB/TrEMBL
      Q8BVG3
      Conserved Domains (1) summary
      pfam03980
      Location:68 → 165
      Nnf1

    2. XM_030252766.1 → XP_030108626.1  polyamine-modulated factor 1 isoform X2

      Conserved Domains (1) summary
      pfam03980
      Location:68 → 119
      Nnf1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPV5.1 GenPept UniProtKB/Swiss-Prot:Q9CPV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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