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    Rgs10 regulator of G-protein signalling 10 [ Mus musculus (house mouse) ]

    Gene ID: 67865, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rgs10provided by MGI
    Official Full Name
    regulator of G-protein signalling 10provided by MGI
    Primary source
    MGI:MGI:1915115
    See related
    Ensembl:ENSMUSG00000030844 AllianceGenome:MGI:1915115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310010N19Rik
    Summary
    Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in G protein-coupled acetylcholine receptor signaling pathway and positive regulation of GTPase activity. Predicted to act upstream of or within negative regulation of signal transduction. Predicted to be located in several cellular components, including axon terminus; dendritic spine; and neuronal cell body. Is expressed in brain; early conceptus; and secondary oocyte. Orthologous to human RGS10 (regulator of G protein signaling 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 15.3), thymus adult (RPKM 13.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 70.16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127975345..128020993, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128373621..128419506, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32707 Neighboring gene STARR-seq mESC enhancer starr_20201 Neighboring gene predicted gene, 39092 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135535641-135535842 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135542158-135542359 Neighboring gene STARR-seq mESC enhancer starr_20202 Neighboring gene predicted gene, 32765 Neighboring gene Tia1 cytotoxic granule-associated RNA binding protein-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135605111-135605220

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RGS10 negatively regulates apical periodontitis via TFEB-mediated autophagy in BABL/c mice model and in vitro. Li J, et al. Int Endod J, 2023 Jul. PMID 37092953
    2. Inhibition of RGS10 Aggravates Periapical Periodontitis via Upregulation of the NF-κB Pathway. Wei W, et al. J Endod, 2022 Oct. PMID 36041584
    3. Inhibition of Rgs10 aggravates periodontitis with collagen-induced arthritis via the nuclear factor-κB pathway. Chan WC, et al. Oral Dis, 2023 May. PMID 35122384
    4. RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice. Almutairi F, et al. Front Immunol, 2021. PMID 34912341, Free PMC Article
    5. Inhibition of regulator of G protein signaling 10, aggravates rheumatoid arthritis progression by promoting NF-κB signaling pathway. Ren J, et al. Mol Immunol, 2021 Jun. PMID 33836352

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling.
      Title: RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling.
    2. RGS10 negatively regulates apical periodontitis via TFEB-mediated autophagy in BABL/c mice model and in vitro.
      Title: RGS10 negatively regulates apical periodontitis via TFEB-mediated autophagy in BABL/c mice model and in vitro.
    3. Inhibition of Rgs10 aggravates periodontitis with collagen-induced arthritis via the nuclear factor-kappaB pathway.
      Title: Inhibition of Rgs10 aggravates periodontitis with collagen-induced arthritis via the nuclear factor-κB pathway.
    4. Inhibition of RGS10 Aggravates Periapical Periodontitis via Upregulation of the NF-kappaB Pathway.
      Title: Inhibition of RGS10 Aggravates Periapical Periodontitis via Upregulation of the NF-κB Pathway.
    5. RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice.
      Title: RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice.
    6. Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
      Title: Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
    7. RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
      Title: RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
    8. Inhibition of regulator of G protein signaling 10, aggravates rheumatoid arthritis progression by promoting NF-kappaB signaling pathway.
      Title: Inhibition of regulator of G protein signaling 10, aggravates rheumatoid arthritis progression by promoting NF-κB signaling pathway.
    9. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
      Title: RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
    10. these observations show that RGS10 serves as an actively regulated node on the platelet signaling network, helping to produce smaller and more densely packed hemostatic thrombi with a greater proportion of fully activated platelets.
      Title: RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129414, AC130474.1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418877.1 → NP_001405806.1  regulator of G-protein signaling 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220

    2. NM_001418878.1 → NP_001405807.1  regulator of G-protein signaling 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220

    3. NM_001418879.1 → NP_001405808.1  regulator of G-protein signaling 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220

    4. NM_001418880.1 → NP_001405809.1  regulator of G-protein signaling 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220

    5. NM_001418881.1 → NP_001405810.1  regulator of G-protein signaling 10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220

    6. NM_001418882.1 → NP_001405811.1  regulator of G-protein signaling 10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC130474
      UniProtKB/TrEMBL
      A0A0U1RPU5
      Related
      ENSMUSP00000146128.2, ENSMUST00000145739.3

    7. NM_026418.3 → NP_080694.1  regulator of G-protein signaling 10 isoform 1

      See identical proteins and their annotated locations for NP_080694.1

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220
      Consensus CDS
      CCDS21896.1
      UniProtKB/Swiss-Prot
      Q9CQE5, Q9D3L2
      UniProtKB/TrEMBL
      Q32MD7
      Related
      ENSMUSP00000033133.6, ENSMUST00000033133.12
      Conserved Domains (1) summary
      cd08741
      Location:42 → 154
      RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein

    RNA

    1. NR_184847.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220

    2. NR_184848.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220

    3. NR_184849.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130474, AC149220

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127975345..128020993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQE5.1 GenPept UniProtKB/Swiss-Prot:Q9CQE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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