Slc22a8 solute carrier family 22 (organic anion transporter), member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a8provided by MGI
Official Full Name: solute carrier family 22 (organic anion transporter), member 8provided by MGI
Primary source: MGI:MGI:1336187
See related: Ensembl:ENSMUSG00000063796 AllianceGenome:MGI:1336187
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oat3; Roct
Summary: Predicted to enable ion transmembrane transporter activity and protein kinase C binding activity. Predicted to be involved in glutathione transport and quaternary ammonium group transport. Predicted to act upstream of or within ion transport and response to toxic substance. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Is expressed in heart; metanephros; nervous system; and thyroid gland. Orthologous to human SLC22A8 (solute carrier family 22 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney adult (RPKM 202.2) See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.44 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8568576..8589199)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8591254..8611835)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.
Title: Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.
Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
Title: Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
Title: Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
OAT3 increases the glucosuric effect of empagliflozin, which may relate to the partial overlap of its localization with SGLT2 and thus OAT3-mediated tubular secretion of empagliflozin in the early proximal tubule.
Title: Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin.
vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.
Title: Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.
OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3, is reported.
Title: Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.
OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney
Title: The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.
Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3).
Title: Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice.
Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.
Title: The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction.
Oat3 also plays a role in bioenergetic pathways.
Title: Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Slc22a8 (e-PCR), detects polymorphism
- UniSTS:463375

Slc22a8 (e-PCR), detects polymorphism
- UniSTS:528864

Roct (e-PCR), detects polymorphism
- UniSTS:144353

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	TAS Traceable Author Statement more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables quaternary ammonium group transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glutathione transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in quaternary ammonium group transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: organic anion transporter 3

Names: organic anion/dicarboxylate exchanger; reduced in osteosclerosis transporter; solute carrier family 22, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164634.2 → NP_001158106.1 organic anion transporter 3 isoform 1

See identical proteins and their annotated locations for NP_001158106.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC025794, AC125136

Consensus CDS

CCDS29537.1

UniProtKB/Swiss-Prot

O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9

Related

ENSMUSP00000131045.2, ENSMUST00000170817.2

Conserved Domains (1) summary

TIGR00898
Location:11 → 503

2A0119; cation transport protein
NM_001164635.2 → NP_001158107.1 organic anion transporter 3 isoform 1

See identical proteins and their annotated locations for NP_001158107.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC025794, AC125136

Consensus CDS

CCDS29537.1

UniProtKB/Swiss-Prot

O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9

Conserved Domains (1) summary

TIGR00898
Location:11 → 503

2A0119; cation transport protein
NM_001411470.1 → NP_001398399.1 organic anion transporter 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC025794, AC125136

UniProtKB/Swiss-Prot

O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9
NM_001411471.1 → NP_001398400.1 organic anion transporter 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC025794, AC125136
NM_001411472.1 → NP_001398401.1 organic anion transporter 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC025794, AC125136
NM_001411473.1 → NP_001398402.1 organic anion transporter 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC025794, AC125136
NM_031194.6 → NP_112471.3 organic anion transporter 3 isoform 1

See identical proteins and their annotated locations for NP_112471.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC025794, AC125136

Consensus CDS

CCDS29537.1

UniProtKB/Swiss-Prot

O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9

Related

ENSMUSP00000010251.4, ENSMUST00000010251.11

Conserved Domains (1) summary

TIGR00898
Location:11 → 503

2A0119; cation transport protein