Angptl4 angiopoietin-like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Angptl4provided by MGI
Official Full Name: angiopoietin-like 4provided by MGI
Primary source: MGI:MGI:1888999
See related: Ensembl:ENSMUSG00000002289 AllianceGenome:MGI:1888999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arp4; Bk89; Fiaf; Ng27; Pgar; Hfarp; Pgarg; Pp1158
Summary: Enables enzyme inhibitor activity. Involved in negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; and triglyceride homeostasis. Acts upstream of or within negative regulation of endothelial cell apoptotic process. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; integumental system; and musculature. Orthologous to human ANGPTL4 (angiopoietin like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 130.4), genital fat pad adult (RPKM 109.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (33993874..34000549, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33774900..33781575, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation.
Title: ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation.
Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis.
Title: Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis.
Knockdown of angiopoietin-like 4 suppresses sepsis-induced acute lung injury by blocking the NF-kappaB pathway activation and hindering macrophage M1 polarization and pyroptosis.
Title: Knockdown of angiopoietin-like 4 suppresses sepsis-induced acute lung injury by blocking the NF-κB pathway activation and hindering macrophage M1 polarization and pyroptosis.
Angiopoietin-like 4 promotes epidermal stem cell proliferation and migration and contributes to cutaneous wound re-epithelialization.
Title: Angiopoietin-like 4 promotes epidermal stem cell proliferation and migration and contributes to cutaneous wound re-epithelialization.
Deficiency of angiopoietin-like 4 enhances CD8[+] T cell bioactivity via metabolic reprogramming for impairing tumour progression.
Title: Deficiency of angiopoietin-like 4 enhances CD8(+) T cell bioactivity via metabolic reprogramming for impairing tumour progression.
Dual role of ANGPTL4 in inflammation.
Title: Dual role of ANGPTL4 in inflammation.
Linoleic acid-induced ANGPTL4 inhibits C2C12 skeletal muscle differentiation by suppressing Wnt/beta-catenin.
Title: Linoleic acid-induced ANGPTL4 inhibits C2C12 skeletal muscle differentiation by suppressing Wnt/β-catenin.
ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation.
Title: ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation.
Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures.
Title: Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures.
ANGPTL4 promotes nephrotic syndrome by downregulating podocyte expression of ACTN4 and podocin.
Title: ANGPTL4 promotes nephrotic syndrome by downregulating podocyte expression of ACTN4 and podocin.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (8) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Angptl4 (e-PCR), detects polymorphism
- UniSTS:463400

Angptl4 (e-PCR), detects polymorphism
- UniSTS:532123

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipoprotein lipase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in protein unfolding	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: angiopoietin-related protein 4

Names: 425O18-1; angiopoietin-like protein 4; fasting-induced adipose factor; fibrinogen/angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; major histocompatibility complex region NG27; secreted protein Bk89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020581.2 → NP_065606.2 angiopoietin-related protein 4 precursor

See identical proteins and their annotated locations for NP_065606.2

Status: VALIDATED

Source sequence(s)

AK014564, AW495750, BY783212

Consensus CDS

CCDS28629.1

UniProtKB/Swiss-Prot

Q78ZJ9, Q9JHX7, Q9JLX7, Q9Z1P8

UniProtKB/TrEMBL

A0A068BEP2

Related

ENSMUSP00000002360.10, ENSMUST00000002360.17

Conserved Domains (2) summary

cd00087
Location:187 → 404

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam08702
Location:104 → 133

Fib_alpha; Fibrinogen alpha/beta chain family