Ppp1r2 protein phosphatase 1, regulatory inhibitor subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r2provided by MGI
Official Full Name: protein phosphatase 1, regulatory inhibitor subunit 2provided by MGI
Primary source: MGI:MGI:1914099
See related: Ensembl:ENSMUSG00000047714 AllianceGenome:MGI:1914099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: I-2; IPP-2; D16Ertd248e; 0610025N14Rik; 2310007G06Rik; 4930440J04Rik; 5430408E15Rik
Summary: Predicted to enable protein domain specific binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of protein binding activity and regulation of phosphoprotein phosphatase activity. Predicted to act upstream of or within glycogen metabolic process. Predicted to be located in cytoplasm; dendritic spine; and growth cone. Is expressed in several structures, including branchial arch; cranial ganglion; dorsal root ganglion; forelimb bud; and sensory organ. Orthologous to several human genes including PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 46.0), lung adult (RPKM 45.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B2; 16 21.41 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (31070359..31094095, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (31251541..31275277, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The three regulators (PPP1R2, PPP1R7, and PPP1R11)share localization with PP1gamma2 in the head and the principal piece of sperm. We show that the association of inhibitors to PP1gamma2 changes during epididymal sperm maturation. In immotile caput epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2, whereas in motile caudal sperm, all three inhibitors are bound as heterodimers or heterotrimers.
Title: Regulators of the protein phosphatase PP1γ2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation.
Protein phosphatase-1 inhibitor-2 acts as a memory suppressor through its positive functional influence on type I protein phosphatase.
Title: Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126659 (e-PCR)
- UniSTS:167182

D16Mit229 (e-PCR), detects polymorphism
- UniSTS:127863

Ppp1r2 (e-PCR), detects polymorphism
- UniSTS:496805

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular function inhibitor activity	EXP Inferred from Experiment more info	PubMed
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase inhibitor 2

NP_080076.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.