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    Akap8l A kinase anchor protein 8-like [ Mus musculus (house mouse) ]

    Gene ID: 54194, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Akap8lprovided by MGI
    Official Full Name
    A kinase anchor protein 8-likeprovided by MGI
    Primary source
    MGI:MGI:1860606
    See related
    Ensembl:ENSMUSG00000002625 AllianceGenome:MGI:1860606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HAP95; Nakap95
    Summary
    Predicted to enable histone deacetylase binding activity; lamin binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including mitotic chromosome condensation; regulation of histone modification; and regulation of mRNA export from nucleus. Located in nuclear matrix. Is expressed in several structures, including central nervous system and retina. Orthologous to human AKAP8L (A-kinase anchoring protein 8 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 62.0), frontal lobe adult (RPKM 58.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.5 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32540398..32569589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32321424..32350616, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene bromodomain containing 4 Neighboring gene predicted gene 4432 Neighboring gene STARR-positive B cell enhancer ABC_E11795 Neighboring gene STARR-positive B cell enhancer ABC_E5590 Neighboring gene STARR-positive B cell enhancer ABC_E955 Neighboring gene A kinase anchor protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E1502 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32506256-32506557 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32508595-32508896 Neighboring gene widely-interspaced zinc finger motifs Neighboring gene STARR-positive B cell enhancer ABC_E4205 Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32540440-32540643 Neighboring gene predicted gene, 53995 Neighboring gene RAS protein activator like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse. Yang Y, et al. J Biol Chem, 2006 Aug 4. PMID 16751186
    2. Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis. Sayer JA, et al. Neuromolecular Med, 2005. PMID 16391387
    3. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    4. Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. Liu H, et al. J Proteome Res, 2017 Sep 1. PMID 28712289
    5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear membrane disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 8-like
    Names
    A kinase (PRKA) anchor protein 8-like
    AKAP8-like protein
    neighbor of A-kinase anchoring protein 95
    neighbor of AKAP95

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403535.1 → NP_001390464.1  A-kinase anchor protein 8-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT033751
      UniProtKB/TrEMBL
      A0A494B9L0
      Related
      ENSMUSP00000157684.2, ENSMUST00000236503.2

    2. NM_001403536.1 → NP_001390465.1  A-kinase anchor protein 8-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT033751

    3. NM_017476.3 → NP_059504.2  A-kinase anchor protein 8-like isoform 1

      See identical proteins and their annotated locations for NP_059504.2

      Status: VALIDATED

      Source sequence(s)
      CT033751
      Consensus CDS
      CCDS50058.1
      UniProtKB/TrEMBL
      Q5RL57, Q9D0K8
      Related
      ENSMUSP00000051389.8, ENSMUST00000050214.9
      Conserved Domains (1) summary
      pfam04988
      Location:389 → 553
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    RNA

    1. NR_175380.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033751

    2. NR_175381.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033751

    3. NR_175382.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033751

    4. NR_175383.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033751

    5. NR_175384.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033751

    6. NR_175385.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033751

    7. NR_175386.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033751

    8. NR_175387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033751

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      32540398..32569589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249905.2 → XP_030105765.1  A-kinase anchor protein 8-like isoform X3

      Conserved Domains (1) summary
      pfam04988
      Location:389 → 512
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    RNA

    1. XR_003952164.2 RNA Sequence

    2. XR_003952155.2 RNA Sequence

    3. XR_004939555.1 RNA Sequence

    4. XR_004939560.1 RNA Sequence

    5. XR_003952163.2 RNA Sequence

    6. XR_003952165.2 RNA Sequence

    7. XR_004939559.1 RNA Sequence

    8. XR_003952151.2 RNA Sequence

    9. XR_003952159.1 RNA Sequence

    10. XR_003952154.2 RNA Sequence

    11. XR_004939558.1 RNA Sequence

    12. XR_004939557.1 RNA Sequence

      Related
      ENSMUST00000236105.2

    13. XR_003952162.2 RNA Sequence

    14. XR_003952161.2 RNA Sequence

    15. XR_004939556.1 RNA Sequence

      Related
      ENSMUST00000236039.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0L7.1 GenPept UniProtKB/Swiss-Prot:Q9R0L7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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