Ulk2 unc-51 like kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ulk2provided by MGI
Official Full Name: unc-51 like kinase 2provided by MGI
Primary source: MGI:MGI:1352758
See related: Ensembl:ENSMUSG00000004798 AllianceGenome:MGI:1352758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Unc51.2; mKIAA0623; A830085I22Rik
Summary: Enables protein serine/threonine kinase activity. Involved in autophagy and response to starvation. Acts upstream of or within axon extension and negative regulation of collateral sprouting. Located in phagophore assembly site membrane. Is expressed in facial bone primordium; nervous system; and sensory organ. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 33.4), CNS E18 (RPKM 21.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61666424..61750754, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61775598..61855334, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function.
Title: Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function.
that skeletal muscle ULK2 has a unique role in basal selective protein degradation by stimulating the recognition and proteolytic sequestration of insoluble ubiquitinated protein aggregates
Title: ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle.
we demonstrate that disrupted expression of the core autophagy proteins ULK1 and ULK2 in mice causes a vacuolar myopathy with ubiquitin and TDP-43-positive inclusions; this myopathy is similar to that caused by VCP/p97 mutations, the most common cause of familial inclusion body myopathy (IBM)
Title: ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.
ULK1 and ULK2 regulate axon guidance during mammalian brain development via a noncanonical (i.e., autophagy-independent) pathway.
Title: The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.
Here we show that Ulk2 heterozygous (Ulk2+/-) mice have upregulated expression of sequestosome-1/p62, an autophagy-associated stress response protein, predominantly in pyramidal neurons of the prefrontal cortex (PFC), and exhibit behavioral deficits associated with the PFC functions, including attenuated sensorimotor gating and impaired cognition
Title: Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons.
Regulation of endoplasmic reticulum-to-Golgi trafficking by ULK1/2 is essential for cellular homeostasis.
Title: The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.
ULK1/2 function as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation.
Title: ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.
autophagy can be executed by mechanisms that are dependent or independent of the ULK1/2-ATG13 interaction.
Title: Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
AnxA2 regulates autophagy, thereby contributing to host immunity against bacteria through the Akt1-mTOR-ULK1/2 signaling pathway
Title: Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway.
ULK2 induced autophagy and inhibited growth in Ras-transformed immortalized Baby Mouse Kidney (iBMK) ATG5(+/+) but not in autophagy-deficient ATG5(-/-) cells.
Title: Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236606

Ulk2 (e-PCR), detects polymorphism
- UniSTS:507303

AU015340 (e-PCR)
- UniSTS:180222

D11Mit260 (e-PCR), detects polymorphism
- UniSTS:126462

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon extension	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collateral sprouting	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatic sensory system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase ULK2

Names: serine/threonine-protein kinase Unc51.2

NP_038909.3

EC 2.7.11.1

XP_006533571.1

EC 2.7.11.1

XP_006533572.1

EC 2.7.11.1

XP_030101926.1

EC 2.7.11.1

XP_036012644.1

EC 2.7.11.1

XP_036012645.1

EC 2.7.11.1

XP_036012646.1

EC 2.7.11.1

XP_036012647.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013881.4 → NP_038909.3 serine/threonine-protein kinase ULK2

See identical proteins and their annotated locations for NP_038909.3

Status: VALIDATED

Source sequence(s)

AK146620, AK148142, AV256860, BM124275

Consensus CDS

CCDS24820.1

UniProtKB/Swiss-Prot

Q80TV7, Q9QY01, Q9WTP4

UniProtKB/TrEMBL

Q3UG39

Related

ENSMUSP00000004920.4, ENSMUST00000004920.4

Conserved Domains (3) summary

smart00220
Location:9 → 271

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14201
Location:2 → 272

STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2

pfam12063
Location:865 → 1030

DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61666424..61750754 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156753.1 → XP_036012646.1 serine/threonine-protein kinase ULK2 isoform X6

UniProtKB/TrEMBL

Q3UG39

Conserved Domains (2) summary

pfam12063
Location:725 → 912

DUF3543; Domain of unknown function (DUF3543)

cl21453
Location:1 → 154

PKc_like; Protein Kinases, catalytic domain
XM_036156752.1 → XP_036012645.1 serine/threonine-protein kinase ULK2 isoform X5

UniProtKB/TrEMBL

Q3UG39

Conserved Domains (2) summary

pfam12063
Location:725 → 904

DUF3543; Domain of unknown function (DUF3543)

cl21453
Location:1 → 154

PKc_like; Protein Kinases, catalytic domain
XM_036156751.1 → XP_036012644.1 serine/threonine-protein kinase ULK2 isoform X2

UniProtKB/TrEMBL

Q3UG39

Conserved Domains (2) summary

pfam12063
Location:809 → 988

DUF3543; Domain of unknown function (DUF3543)

cl21453
Location:2 → 238

PKc_like; Protein Kinases, catalytic domain
XM_030246066.2 → XP_030101926.1 serine/threonine-protein kinase ULK2 isoform X4

UniProtKB/TrEMBL

Q3UG39

Conserved Domains (2) summary

cd14201
Location:2 → 272

STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2

pfam12063
Location:802 → 984

DUF3543; Domain of unknown function (DUF3543)
XM_006533509.5 → XP_006533572.1 serine/threonine-protein kinase ULK2 isoform X3

UniProtKB/TrEMBL

Q3UG39

Conserved Domains (2) summary

cd14201
Location:2 → 272

STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2

pfam12063
Location:802 → 973

DUF3543; Domain of unknown function (DUF3543)
XM_036156754.1 → XP_036012647.1 serine/threonine-protein kinase ULK2 isoform X7

Conserved Domains (1) summary

pfam12063
Location:367 → 546

DUF3543; Domain of unknown function (DUF3543)
XM_006533508.5 → XP_006533571.1 serine/threonine-protein kinase ULK2 isoform X1

UniProtKB/TrEMBL

Q3UG39

Conserved Domains (2) summary

cd14201
Location:2 → 272

STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2

pfam12063
Location:848 → 1019

DUF3543; Domain of unknown function (DUF3543)