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    Fbxo8 F-box protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 50753, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Fbxo8provided by MGI
    Official Full Name
    F-box protein 8provided by MGI
    Primary source
    MGI:MGI:1354696
    See related
    Ensembl:ENSMUSG00000038206 AllianceGenome:MGI:1354696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx8
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Part of ubiquitin ligase complex. Is expressed in several structures, including branchial arch; ear; forelimb bud; heart; and notochord. Orthologous to human FBXO8 (F-box protein 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.5), kidney adult (RPKM 7.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B2; 8 29.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (57004189..57046974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (56551154..56593939)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930518J21 gene Neighboring gene STARR-seq mESC enhancer starr_21518 Neighboring gene predicted gene, 24375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:59029623-59029732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:59030027-59030210 Neighboring gene STARR-positive B cell enhancer mm9_chr8:59030212-59030513 Neighboring gene centrosomal protein 44 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21519 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21521 Neighboring gene VISTA enhancer mm1687 Neighboring gene predicted gene, 33501

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fbx8 makes Arf6 refractory to function via ubiquitination. Yano H, et al. Mol Biol Cell, 2008 Mar. PMID 18094045, Free PMC Article
    2. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
    3. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
    4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fbx8, an F-box protein bearing the Sec7 domain, mediates ubiquitination of Arf6.
      Title: Fbx8 makes Arf6 refractory to function via ubiquitination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368347.1 → NP_001355276.1  F-box only protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116121
      Conserved Domains (1) summary
      cd00171
      Location:1 → 155
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    2. NM_001368348.1 → NP_001355277.1  F-box only protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116121
      Conserved Domains (1) summary
      cd00171
      Location:1 → 155
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    3. NM_015791.4 → NP_056606.2  F-box only protein 8 isoform 1

      See identical proteins and their annotated locations for NP_056606.2

      Status: VALIDATED

      Source sequence(s)
      AC116121
      Consensus CDS
      CCDS22314.1
      UniProtKB/Swiss-Prot
      Q8JZY7, Q9QZN3
      UniProtKB/TrEMBL
      Q8BP70
      Related
      ENSMUSP00000037544.6, ENSMUST00000040218.13
      Conserved Domains (2) summary
      cd00171
      Location:133 → 312
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      pfam12937
      Location:74 → 112
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      57004189..57046974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZN3.2 GenPept UniProtKB/Swiss-Prot:Q9QZN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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