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    Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a [ Mus musculus (house mouse) ]

    Gene ID: 27279, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tnfrsf12aprovided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 12aprovided by MGI
    Primary source
    MGI:MGI:1351484
    See related
    Ensembl:ENSMUSG00000023905 AllianceGenome:MGI:1351484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fn14; HPIP; TweakR; TWEAK-R
    Summary
    Involved in regulation of angiogenesis. Acts upstream of or within extrinsic apoptotic signaling pathway; positive regulation of axon extension; and substrate-dependent cell migration, cell attachment to substrate. Located in cell surface; plasma membrane; and ruffle. Is expressed in several structures, including adrenal medulla; genitourinary system; heart; limb long bone; and molar. Orthologous to human TNFRSF12A (TNF receptor superfamily member 12A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 44.7), ovary adult (RPKM 38.8) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 11.99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23894419..23896423, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23675445..23677449, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene BICD family like cargo adaptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E8656 Neighboring gene THO complex 6 Neighboring gene host cell factor C1 regulator 1 (XPO1-dependent) Neighboring gene claudin 6 Neighboring gene claudin 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia. Short C, et al. Hepatology, 2023 May 1. PMID 36626628
    2. Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy. Tomaz da Silva M, et al. FASEB J, 2022 Dec. PMID 36412933, Free PMC Article
    3. Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice. Guan XX, et al. Mol Med, 2022 Jul 30. PMID 35907805, Free PMC Article
    4. Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells. Luo M, et al. Inflamm Res, 2021 May. PMID 33755760
    5. Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration. Nagy D, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33526652, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury.
      Title: Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury.
    2. Fn14 promotes myoblast fusion during regenerative myogenesis.
      Title: Fn14 promotes myoblast fusion during regenerative myogenesis.
    3. Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia.
      Title: Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia.
    4. TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia.
      Title: TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia.
    5. Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice.
      Title: Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice.
    6. Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy.
      Title: Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy.
    7. Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice.
      Title: Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice.
    8. Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice.
      Title: Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice.
    9. Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells.
      Title: Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells.
    10. TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease.
      Title: TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within substrate-dependent cell migration, cell attachment to substrate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 12A
    Names
    FGF-inducible 14
    fibroblast growth factor-inducible immediate-early response protein 14
    fibroblast growth factor-regulated protein 2
    tweak-receptor
    type I transmembrane protein Fn14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161746.1 → NP_001155218.1  tumor necrosis factor receptor superfamily member 12A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI853177, AK160136, DV655788
      Consensus CDS
      CCDS50011.1
      UniProtKB/TrEMBL
      E9PZT5
      Related
      ENSMUSP00000131574.2, ENSMUST00000167059.9
      Conserved Domains (1) summary
      cl22855
      Location:1 → 94
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    2. NM_013749.2 → NP_038777.2  tumor necrosis factor receptor superfamily member 12A isoform 1 precursor

      See identical proteins and their annotated locations for NP_038777.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI853177, AK160136
      Consensus CDS
      CCDS28456.1
      UniProtKB/Swiss-Prot
      Q3TVG8, Q9CR75, Q9QZW3
      Related
      ENSMUSP00000024698.9, ENSMUST00000024698.10
      Conserved Domains (2) summary
      cd13413
      Location:9 → 33
      TNFRSF12A; CRD1 [structural motif]
      cl22855
      Location:1 → 129
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23894419..23896423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR75.1 GenPept UniProtKB/Swiss-Prot:Q9CR75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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