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    Krt4 keratin 4 [ Mus musculus (house mouse) ]

    Gene ID: 16682, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Krt4provided by MGI
    Official Full Name
    keratin 4provided by MGI
    Primary source
    MGI:MGI:96701
    See related
    Ensembl:ENSMUSG00000059668 AllianceGenome:MGI:96701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K4; Krt2-4; Krt-2.4
    Summary
    Involved in epithelial cell differentiation and negative regulation of epithelial cell proliferation. Predicted to be located in cell surface and keratin filament. Is expressed in several structures, including alimentary system; lower urinary tract; sensory organ; skin; and trachea. Used to study hereditary mucosal leukokeratosis. Human ortholog(s) of this gene implicated in hereditary mucosal leukokeratosis. Orthologous to human KRT4 (keratin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 371.2), stomach adult (RPKM 351.0) and 1 other tissue See more
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    Genomic context

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    See Krt4 in Genome Data Viewer
    Location:
    15 F2; 15 57.13 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101826970..101833170, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101918535..101924735, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39807 Neighboring gene keratin 77 Neighboring gene keratin 76 Neighboring gene keratin 79 Neighboring gene keratin 78

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a Keratin 4 mutation in a chemically induced mouse mutant that models white sponge nevus. McGowan KA, et al. J Invest Dermatol, 2007 Jan. PMID 16858417
    2. Mouse keratin 4 is necessary for internal epithelial integrity. Ness SL, et al. J Biol Chem, 1998 Sep 11. PMID 9727004
    3. Nucleotide sequence of mouse EndoA cytokeratin cDNA reveals polypeptide characteristics of the type-II keratin subfamily. Morita T, et al. Gene, 1988 Aug 15. PMID 2464527
    4. [Mouse type II cytokeratin genes CK-4 and CK-8 mapped on chromosome 15]. Zhao SY. Yi Chuan Xue Bao, 1991. PMID 1722687
    5. Polarized and functional epithelia can form after the targeted inactivation of both mouse keratin 8 alleles. Baribault H, et al. J Cell Biol, 1991 Dec. PMID 1721911, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in keratin filament TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    keratin, type II cytoskeletal 4
    Names
    57kDa keratin
    57kd keratin
    CK-4
    cytokeratin-4
    cytoskeletal 57 kDa keratin
    keratin complex 2, basic, gene 4
    type-II keratin Kb4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008475.2 → NP_032501.2  keratin, type II cytoskeletal 4

      See identical proteins and their annotated locations for NP_032501.2

      Status: VALIDATED

      Source sequence(s)
      BC064008, BY139439
      Consensus CDS
      CCDS37222.1
      UniProtKB/Swiss-Prot
      A6H6D6, P07744, Q6P3F5
      Related
      ENSMUSP00000023797.7, ENSMUST00000023797.8
      Conserved Domains (3) summary
      pfam00038
      Location:146 → 458
      Filament; Intermediate filament protein
      pfam16208
      Location:14 → 142
      Keratin_2_head; Keratin type II head
      cl23720
      Location:366 → 433
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101826970..101833170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07744.2 GenPept UniProtKB/Swiss-Prot:P07744

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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