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    Pus1 pseudouridine synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 56361, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pus1provided by MGI
    Official Full Name
    pseudouridine synthase 1provided by MGI
    Primary source
    MGI:MGI:1929237
    See related
    Ensembl:ENSMUSG00000029507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPU; MPUS1; mPus1p; A730013B20Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 13.1), liver E14 (RPKM 13.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pus1 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110921533..110928523, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110773667..110780649, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (111202686..111209634, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene E1A binding protein p400 Neighboring gene predicted gene, 26079 Neighboring gene predicted gene, 22583 Neighboring gene predicted gene 15559 Neighboring gene unc-51 like kinase 1 Neighboring gene ES cell cis-regulatory motif 10b Neighboring gene HscB iron-sulfur cluster co-chaperone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables pseudouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pseudouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid receptor RNA activator RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA pseudouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within tRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tRNA pseudouridine synthase A
    Names
    tRNA pseudouridine synthase A, mitochondrial
    tRNA pseudouridine(38-40) synthase
    tRNA pseudouridylate synthase I
    tRNA-uridine isomerase I
    NP_001020732.1
    NP_001020733.1
    NP_001334319.1
    NP_001346147.1
    NP_001346148.1
    NP_062674.2
    XP_006535211.1
    XP_017176503.1
    XP_017176504.1
    XP_036021224.1
    XP_036021225.1
    XP_036021226.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025561.3NP_001020732.1  tRNA pseudouridine synthase A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC161348
      Consensus CDS
      CCDS19530.1
      UniProtKB/TrEMBL
      H7BX59
      Related
      ENSMUSP00000083844.6, ENSMUST00000086643.12
      Conserved Domains (2) summary
      cd02568
      Location:84354
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
      COG0101
      Location:80377
      TruA; tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]
    2. NM_001025562.2NP_001020733.1  tRNA pseudouridine synthase A isoform 3

      See identical proteins and their annotated locations for NP_001020733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and 5' coding region and lacks an in-frame segment in the coding region, as compared to variant 1. These differences cause translation initiation at a downstream AUG and an encoded protein (isoform 3) that is shorter than isoform 1. Variants 3 and 6 both encode the same isoform (3).
      Source sequence(s)
      AF116237, BY174054, CF618003
      Consensus CDS
      CCDS39212.1
      UniProtKB/Swiss-Prot
      Q9WU56
      Related
      ENSMUSP00000130814.2, ENSMUST00000170468.8
      Conserved Domains (1) summary
      cd02568
      Location:54306
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    3. NM_001347390.1NP_001334319.1  tRNA pseudouridine synthase A isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and 5' coding region and lacks two in-frame segments in the coding region, as compared to variant 1. These differences cause translation initiation at a downstream AUG and an encoded protein (isoform 4) that is shorter than isoform 1.
      Source sequence(s)
      AC161348
      Consensus CDS
      CCDS84929.1
      UniProtKB/Swiss-Prot
      Q9WU56
      Related
      ENSMUSP00000108045.2, ENSMUST00000112426.8
    4. NM_001359218.1NP_001346147.1  tRNA pseudouridine synthase A isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC161348
      Conserved Domains (1) summary
      cd02568
      Location:54324
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    5. NM_001359219.1NP_001346148.1  tRNA pseudouridine synthase A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to variant 1. Variants 3 and 6 both encode the same isoform (3).
      Source sequence(s)
      AC161348, AK161521
      Consensus CDS
      CCDS39212.1
      Related
      ENSMUSP00000031481.7, ENSMUST00000031481.13
      Conserved Domains (1) summary
      cd02568
      Location:54306
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    6. NM_019700.4NP_062674.2  tRNA pseudouridine synthase A isoform 2

      See identical proteins and their annotated locations for NP_062674.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BU515425, BY331510, CB059120, CF618003
      Consensus CDS
      CCDS19531.1
      UniProtKB/Swiss-Prot
      Q9WU56
      Related
      ENSMUSP00000031483.9, ENSMUST00000031483.15
      Conserved Domains (2) summary
      cd02568
      Location:84336
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
      COG0101
      Location:80359
      TruA; tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110921533..110928523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165333.1XP_036021226.1  tRNA pseudouridine synthase A isoform X1

      Conserved Domains (1) summary
      cd02568
      Location:54324
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    2. XM_017321015.3XP_017176504.1  tRNA pseudouridine synthase A isoform X2

      UniProtKB/Swiss-Prot
      Q9WU56
      Conserved Domains (1) summary
      cd02568
      Location:54306
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    3. XM_036165332.1XP_036021225.1  tRNA pseudouridine synthase A isoform X1

      Conserved Domains (1) summary
      cd02568
      Location:54324
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    4. XM_017321014.2XP_017176503.1  tRNA pseudouridine synthase A isoform X2

      UniProtKB/Swiss-Prot
      Q9WU56
      Conserved Domains (1) summary
      cd02568
      Location:54306
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    5. XM_036165331.1XP_036021224.1  tRNA pseudouridine synthase A isoform X1

      Conserved Domains (1) summary
      cd02568
      Location:54324
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    6. XM_006535148.3XP_006535211.1  tRNA pseudouridine synthase A isoform X3

      Conserved Domains (1) summary
      cd02568
      Location:84290
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
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