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    Camkk1 calcium/calmodulin-dependent protein kinase kinase 1, alpha [ Mus musculus (house mouse) ]

    Gene ID: 55984, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Camkk1provided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase kinase 1, alphaprovided by MGI
    Primary source
    MGI:MGI:1891766
    See related
    Ensembl:ENSMUSG00000020785 AllianceGenome:MGI:1891766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Camkk; caMKK 1; caM-KK 1; CaMKKalpha; caMKK alpha; caM-KK alpha
    Summary
    Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in activation of protein kinase activity and intracellular signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 25.3), cortex adult (RPKM 17.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B4; 11 45.12 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72906869..72932899)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73016043..73042073)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7013 Neighboring gene ATPase, Ca++ transporting, ubiquitous Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72820103-72820212 Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72828695-72828896 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 1 Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene nuclear cap binding subunit 3 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564 Neighboring gene STARR-seq mESC enhancer starr_29927 Neighboring gene integrin alpha E, epithelial-associated Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72921846-72921999 Neighboring gene histone H3 associated protein kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Constitutively active CaMKKα stimulates skeletal muscle glucose uptake in insulin-resistant mice in vivo. Hinkley JM, et al. Diabetes, 2014 Jan. PMID 24101676, Free PMC Article
    2. Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory. Kaitsuka T, et al. Neurobiol Learn Mem, 2011 Sep. PMID 21558011
    3. Novel Ca2+/calmodulin-dependent protein kinase expressed in actively growing mycelia of the basidiomycetous mushroom Coprinus cinereus. Kaneko K, et al. Biochim Biophys Acta, 2009 Jan 1. PMID 18786613
    4. Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes. Shen QW, et al. Am J Physiol Cell Physiol, 2007 Oct. PMID 17687000
    5. Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation. Witczak CA, et al. Diabetes, 2007 May. PMID 17287469

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the CaMKK-CaMKIalpha cascade is required for the axonal growth effect of Wnt5a during neuronal polarization.
      Title: Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization.
    2. Data (including data from knockout mice) suggest that up-regulation of Camkk1 and calcium signaling stimulates muscle growth via up-regulation of mTORC1 (mammalian target of rapamycin complex 1) signaling and muscle protein biosynthesis.
      Title: Constitutive activation of CaMKKα signaling is sufficient but not necessary for mTORC1 activation and growth in mouse skeletal muscle.
    3. caCaMKKalpha stimulates glucose uptake additively with insulin, and in insulin-resistant muscle, and alters the phosphorylation of TBC1D1/TBC1D4.
      Title: Constitutively active CaMKKα stimulates skeletal muscle glucose uptake in insulin-resistant mice in vivo.
    4. Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways
      Title: Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.
    5. Data show that CaMKK is the kinase responsible for alpha-lipoic acid induced AMP-activated protein kinase activation in C2C12 myotubes.
      Title: Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes.
    6. In muscles from wild-type mice CaMKKalpha increased in vivo deoxyglucose uptake and AMPKalpha1 and -alpha2 activities 2.5-fold.
      Title: Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation.
    7. ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI
      Title: Calcium activation of ERK mediated by calmodulin kinase I.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase kinase 1
    Names
    caM-kinase IV kinase
    caM-kinase kinase 1
    caM-kinase kinase alpha
    calcium calmodulin dependent protein kinase kinase alpha
    NP_001349770.1
    NP_061371.2
    XP_006533824.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362841.1 → NP_001349770.1  calcium/calmodulin-dependent protein kinase kinase 1

      Status: VALIDATED

      Source sequence(s)
      AI843712, AL670399
      Consensus CDS
      CCDS24993.1
      UniProtKB/Swiss-Prot
      Q8VBY2, Q9R054
      Conserved Domains (1) summary
      cd14200
      Location:127 → 410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

    2. NM_018883.3 → NP_061371.2  calcium/calmodulin-dependent protein kinase kinase 1

      See identical proteins and their annotated locations for NP_061371.2

      Status: VALIDATED

      Source sequence(s)
      AI846603, AK144483, AL670399
      Consensus CDS
      CCDS24993.1
      UniProtKB/Swiss-Prot
      Q8VBY2, Q9R054
      Related
      ENSMUSP00000090613.7, ENSMUST00000092937.13
      Conserved Domains (1) summary
      cd14200
      Location:127 → 410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

    RNA

    1. NR_156179.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI843712, AK144483, AL670399
      Related
      ENSMUST00000155720.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72906869..72932899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533761.4 → XP_006533824.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006533824.1

      UniProtKB/Swiss-Prot
      Q8VBY2, Q9R054
      Conserved Domains (1) summary
      cd14200
      Location:127 → 410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBY2.1 GenPept UniProtKB/Swiss-Prot:Q8VBY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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