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    Baat bile acid-Coenzyme A: amino acid N-acyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 12012, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Baatprovided by MGI
    Official Full Name
    bile acid-Coenzyme A: amino acid N-acyltransferaseprovided by MGI
    Primary source
    MGI:MGI:106642
    See related
    Ensembl:ENSMUSG00000039653 AllianceGenome:MGI:106642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BAT
    Summary
    Enables N-acyltransferase activity. Acts upstream of or within bile acid metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in disease of metabolism. Orthologous to human BAAT (bile acid-CoA:amino acid N-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 17.8), liver E18 (RPKM 3.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B1; 4 26.51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49489416..49507915, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49489416..49507915, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene acyl-coenzyme A amino acid N-acyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_10184 Neighboring gene predicted gene, 26424 Neighboring gene predicted gene, 33009 Neighboring gene predicted gene, 32894 Neighboring gene predicted gene, 52736 Neighboring gene mitochondrial ribosomal protein L50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice. Neugebauer KA, et al. J Lipid Res, 2022 Dec. PMID 36243101, Free PMC Article
    2. Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26. Contos JJ, et al. Genomics, 1998 Aug 1. PMID 9721207
    3. The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine. O'Byrne J, et al. J Biol Chem, 2003 Sep 5. PMID 12810727
    4. Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase. Sfakianos MK, et al. J Biol Chem, 2002 Dec 6. PMID 12239217
    5. Genetic mapping of the C-type natriuretic peptide receptor (Npr2) gene to mouse chromosome 4. Nuglozeh E, et al. Mamm Genome, 1997 Aug. PMID 9250880

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choloyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine N-choloyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thiolester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid conjugation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bile acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in taurine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bile acid-CoA:amino acid N-acyltransferase
    Names
    BACAT
    bile acid-CoA thioesterase
    bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase
    choloyl-CoA hydrolase
    glycine N-choloyltransferase
    long-chain fatty-acyl-CoA hydrolase
    taurine N-acyltransferase
    NP_031545.2
    XP_006537628.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007519.3 → NP_031545.2  bile acid-CoA:amino acid N-acyltransferase

      See identical proteins and their annotated locations for NP_031545.2

      Status: VALIDATED

      Source sequence(s)
      AA255212, AK017923, BB800891, BY080271, CB947692, U95215
      Consensus CDS
      CCDS18173.1
      UniProtKB/Swiss-Prot
      A2AKK7, O08833, Q8C1I3, Q91X34
      Related
      ENSMUSP00000041983.3, ENSMUST00000043056.9
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 414
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:14 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      49489416..49507915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537565.4 → XP_006537628.1  bile acid-CoA:amino acid N-acyltransferase isoform X1

      Conserved Domains (1) summary
      pfam08840
      Location:34 → 241
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91X34.1 GenPept UniProtKB/Swiss-Prot:Q91X34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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