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    St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 20449, updated on 23-Jun-2021

    Summary

    Official Symbol
    St8sia1provided by MGI
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by MGI
    Primary source
    MGI:MGI:106011
    See related
    Ensembl:ENSMUSG00000030283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Si; GD3; GD3S; Sia-T; Siat8; Siat8a; 9330109E03Rik
    Expression
    Biased expression in thymus adult (RPKM 5.6), kidney adult (RPKM 5.0) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See St8sia1 in Genome Data Viewer
    Location:
    6 G3; 6 74.78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142767267..142935247, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142821541..142989528, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142770061..142912972, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53249 Neighboring gene cytidine monophospho-N-acetylneuraminic acid synthetase Neighboring gene predicted gene, 46981 Neighboring gene sulfotransferase family 6B, member 2 Neighboring gene predicted gene 7457 Neighboring gene predicted gene 7468 Neighboring gene C2 calcium-dependent domain containing 5 Neighboring gene predicted gene, 31108 Neighboring gene predicted gene, 38921

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
    Names
    GD3 synthase
    SIAT8-A
    ST8Sia I
    ST8SiaI
    alpha-2, 8-sialyltransferase
    alpha-2,8-sialyltransferase 8A
    ganglioside GD3 synthase
    ganglioside GT3 synthase
    sialyltransferase 8 A
    sialyltransferase 8A
    sialyltransferase St8Sia I
    sialytransferase St8Sia I
    NP_035504.2
    XP_006506991.1
    XP_006506992.1
    XP_006506993.1
    XP_011239876.1
    XP_011239877.1
    XP_011239878.1
    XP_017176961.1
    XP_030111143.1
    XP_036021874.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011374.2NP_035504.2  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

      See identical proteins and their annotated locations for NP_035504.2

      Status: VALIDATED

      Source sequence(s)
      AC122483, BC024821
      Consensus CDS
      CCDS20689.1
      UniProtKB/Swiss-Prot
      Q64687
      Related
      ENSMUSP00000032421.4, ENSMUST00000032421.4
      Conserved Domains (1) summary
      pfam00777
      Location:91343
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142767267..142935247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241575.3XP_011239877.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      See identical proteins and their annotated locations for XP_011239877.1

      UniProtKB/TrEMBL
      Q3V3B1
      Conserved Domains (1) summary
      pfam00777
      Location:11263
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. XM_006506929.4XP_006506992.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006506992.1

      UniProtKB/TrEMBL
      Q3V3B1
      Conserved Domains (1) summary
      pfam00777
      Location:11263
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    3. XM_006506930.5XP_006506993.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006506993.1

      UniProtKB/TrEMBL
      Q3V3B1
      Conserved Domains (1) summary
      pfam00777
      Location:11263
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    4. XM_017321472.3XP_017176961.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4

      Conserved Domains (1) summary
      pfam00777
      Location:20200
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    5. XM_030255283.1XP_030111143.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4

      Conserved Domains (1) summary
      pfam00777
      Location:20200
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    6. XM_006506928.4XP_006506991.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006506991.1

      UniProtKB/TrEMBL
      Q3V3B1
      Conserved Domains (1) summary
      pfam00777
      Location:11263
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    7. XM_011241574.2XP_011239876.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:20272
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    8. XM_011241576.4XP_011239878.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X3

      Conserved Domains (1) summary
      pfam00777
      Location:91198
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    9. XM_036165981.1XP_036021874.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:91194
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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