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    Ppp1r3f protein phosphatase 1, regulatory subunit 3F [ Mus musculus (house mouse) ]

    Gene ID: 54646, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp1r3fprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 3Fprovided by MGI
    Primary source
    MGI:MGI:1859617
    See related
    Ensembl:ENSMUSG00000039556 AllianceGenome:MGI:1859617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R3F; RF3; Sfc15; DXImx48e
    Summary
    Predicted to enable glycogen binding activity and protein phosphatase 1 binding activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within regulation of glycogen (starch) synthase activity. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Is expressed in left lung and right lung. Orthologous to human PPP1R3F (protein phosphatase 1 regulatory subunit 3F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.3), cortex adult (RPKM 5.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp1r3f in Genome Data Viewer
    Location:
    X A1.1; X 3.4 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7424815..7440541, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7558562..7574281, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene kelch-like 21 pseudogene Neighboring gene predicted gene, 23082 Neighboring gene STARR-positive B cell enhancer mm9_chrX:7151387-7151688 Neighboring gene Foxp3 regulating long intergenic noncoding RNA Neighboring gene forkhead box P3 Neighboring gene coiled-coil domain containing 22 Neighboring gene calcium channel, voltage-dependent, alpha 1F subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals. Kelsall IR, et al. J Neurochem, 2011 Aug. PMID 21668450
    2. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001
    3. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
    4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycogen binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of glycogen (starch) synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 3F
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 3F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290574.2 → NP_001277503.1  protein phosphatase 1 regulatory subunit 3F isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL731793
      Consensus CDS
      CCDS72328.1
      UniProtKB/TrEMBL
      B9EHL3
      Related
      ENSMUSP00000122903.2, ENSMUST00000150787.8
      Conserved Domains (1) summary
      pfam03370
      Location:162 → 282
      CBM_21; Carbohydrate/starch-binding module (family 21)

    2. NM_138605.4 → NP_613071.3  protein phosphatase 1 regulatory subunit 3F isoform 2

      See identical proteins and their annotated locations for NP_613071.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL731793
      Consensus CDS
      CCDS29964.2
      UniProtKB/Swiss-Prot
      B1AW09, B1AW10, Q3UGL4, Q6PCL6, Q9JIG4
      UniProtKB/TrEMBL
      B9EHL3
      Related
      ENSMUSP00000111407.4, ENSMUST00000115742.9
      Conserved Domains (1) summary
      pfam03370
      Location:163 → 282
      CBM_21; Carbohydrate/starch-binding module (family 21)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7424815..7440541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIG4.3 GenPept UniProtKB/Swiss-Prot:Q9JIG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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