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    Eln elastin [ Mus musculus (house mouse) ]

    Gene ID: 13717, updated on 13-Jun-2021

    Summary

    Official Symbol
    Elnprovided by MGI
    Official Full Name
    elastinprovided by MGI
    Primary source
    MGI:MGI:95317
    See related
    Ensembl:ENSMUSG00000029675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI385707; AI480567; E030024M20Rik
    Summary
    This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in lung adult (RPKM 131.3), limb E14.5 (RPKM 72.1) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Eln in Genome Data Viewer
    Location:
    5 G2; 5 74.76 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134731449..134776300, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134702595..134747368, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135178466..135223124, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene LIM-domain containing, protein kinase Neighboring gene predicted gene 10369 Neighboring gene predicted gene, 30003 Neighboring gene transmembrane protein 270 Neighboring gene claudin 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007925.4NP_031951.2  elastin precursor

      See identical proteins and their annotated locations for NP_031951.2

      Status: REVIEWED

      Source sequence(s)
      AA183434, AC091250, AK041860
      Consensus CDS
      CCDS19725.1
      UniProtKB/Swiss-Prot
      P54320
      Related
      ENSMUSP00000015138.10, ENSMUST00000015138.13

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134731449..134776300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240855.3XP_011239157.1  elastin isoform X1

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