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    Snap23 synaptosomal-associated protein 23 [ Mus musculus (house mouse) ]

    Gene ID: 20619, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Snap23provided by MGI
    Official Full Name
    synaptosomal-associated protein 23provided by MGI
    Primary source
    MGI:MGI:109356
    See related
    Ensembl:ENSMUSG00000027287 AllianceGenome:MGI:109356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sndt; 23kDa; Syndet; SNAP-23
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Acts upstream of or within exocytosis. Located in cytoplasmic vesicle and plasma membrane. Part of SNARE complex. Is expressed in testis. Orthologous to human SNAP23 (synaptosome associated protein 23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 10.3), bladder adult (RPKM 8.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snap23 in Genome Data Viewer
    Location:
    2 60.37 cM; 2 E5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120398137..120436829)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120567655..120601255)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene STARR-seq mESC enhancer starr_05508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120308865-120309066 Neighboring gene calpain 3 Neighboring gene STARR-seq mESC enhancer starr_05509 Neighboring gene zinc finger protein 106 Neighboring gene STARR-seq mESC enhancer starr_05510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120393240-120393349 Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene leucine rich repeat containing 57 Neighboring gene STARR-positive B cell enhancer ABC_E414 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene StAR related lipid transfer domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_05514 Neighboring gene codanin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation. Huang M, et al. iScience, 2023 May 19. PMID 37168570, Free PMC Article
    2. The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis. Gentile GM, et al. FASEB J, 2022 Aug. PMID 35816155, Free PMC Article
    3. SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis. Cardenas RA, et al. J Biol Chem, 2021 Jan-Jun. PMID 33837726, Free PMC Article
    4. Platelet-specific deletion of SNAP23 ablates granule secretion, substantially inhibiting arterial and venous thrombosis in mice. Williams CM, et al. Blood Adv, 2018 Dec 26. PMID 30573565, Free PMC Article
    5. Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells. Kunii M, et al. J Cell Biol, 2016 Oct 10. PMID 27697926, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice.
      Title: SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice.
    2. The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis.
      Title: The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis.
    3. SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.
      Title: SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.
    4. SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
      Title: SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
    5. Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
      Title: Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
    6. The Kif5-SNAP23 complex interacts with mGlu1a receptor.
      Title: SNAP23-Kif5 complex controls mGlu1 receptor trafficking.
    7. Data demonstrate a role for SNAP23 in the control of adipocytemacroautophagy and programmed cell death through an ATG9-dependent, but ATG7-independent, pathway regulating BAX protein levels and BAX activation.
      Title: SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy.
    8. Findings suggest that stx11 regulates the stimulus-dependent transport of TLR4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Our results clarify the regulatory mechanisms underlying intracellular transport of TLR4 and have implications for microbial pathogenesis and immune responses.
      Title: Syntaxin 11 regulates the stimulus-dependent transport of Toll-like receptor 4 to the plasma membrane by cooperating with SNAP-23 in macrophages.
    9. SNAP-23 phosphorylation at Ser95 played an important role in the regulation of SNARE-dependent membrane fusion during FcR-mediated phagocytosis.
      Title: Phosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages.
    10. PKM2 promotes tumor cell exosome release via phosphorylating protein SNAP23.
      Title: Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in histamine secretion by mast cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in specific granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptosomal-associated protein 23
    Names
    synaptosomal-associated protein, 23kD
    vesicle-membrane fusion protein SNAP-23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177792.2 → NP_001171263.1  synaptosomal-associated protein 23 isoform a

      See identical proteins and their annotated locations for NP_001171263.1

      Status: VALIDATED

      Source sequence(s)
      AL772299
      Consensus CDS
      CCDS50681.1
      UniProtKB/TrEMBL
      Q9D3L3
      Related
      ENSMUSP00000112138.2, ENSMUST00000116437.8
      Conserved Domains (3) summary
      cd15884
      Location:159 → 217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100 → 157
      SNAP-25; SNAP-25 family

    2. NM_001177793.2 → NP_001171264.1  synaptosomal-associated protein 23 isoform b

      See identical proteins and their annotated locations for NP_001171264.1

      Status: VALIDATED

      Source sequence(s)
      AL772299
      Consensus CDS
      CCDS16622.1
      UniProtKB/Swiss-Prot
      O09044, O35620
      UniProtKB/TrEMBL
      A2AKH4
      Related
      ENSMUSP00000028743.4, ENSMUST00000028743.10
      Conserved Domains (3) summary
      cd15884
      Location:148 → 206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86 → 146
      SNAP-25; SNAP-25 family

    3. NM_001412626.1 → NP_001399555.1  synaptosomal-associated protein 23 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL772299
      UniProtKB/Swiss-Prot
      O09044, O35620
      UniProtKB/TrEMBL
      A2AKH4

    4. NM_001412627.1 → NP_001399556.1  synaptosomal-associated protein 23 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL772299
      UniProtKB/Swiss-Prot
      O09044, O35620
      UniProtKB/TrEMBL
      A2AKH4

    5. NM_001412628.1 → NP_001399557.1  synaptosomal-associated protein 23 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL772299

    6. NM_001412629.1 → NP_001399558.1  synaptosomal-associated protein 23 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL772299

    7. NM_001412630.1 → NP_001399559.1  synaptosomal-associated protein 23 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL772299
      Related
      ENSMUSP00000116935.2, ENSMUST00000142278.2

    8. NM_001412631.1 → NP_001399560.1  synaptosomal-associated protein 23 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL772299

    9. NM_001412632.1 → NP_001399561.1  synaptosomal-associated protein 23 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL772299

    10. NM_001412633.1 → NP_001399562.1  synaptosomal-associated protein 23 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL772299

    11. NM_009222.4 → NP_033248.1  synaptosomal-associated protein 23 isoform b

      See identical proteins and their annotated locations for NP_033248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform b).
      Source sequence(s)
      AL772299
      Consensus CDS
      CCDS16622.1
      UniProtKB/Swiss-Prot
      O09044, O35620
      UniProtKB/TrEMBL
      A2AKH4
      Related
      ENSMUSP00000106339.3, ENSMUST00000110711.9
      Conserved Domains (3) summary
      cd15884
      Location:148 → 206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86 → 146
      SNAP-25; SNAP-25 family

    RNA

    1. NR_182010.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772299

    2. NR_182011.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772299

    3. NR_182012.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772299

    4. NR_182013.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772299

    5. NR_182014.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772299

    6. NR_182015.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772299

    7. NR_182016.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772299

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120398137..120436829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499056.5 → XP_006499119.1  synaptosomal-associated protein 23 isoform X1

      See identical proteins and their annotated locations for XP_006499119.1

      UniProtKB/TrEMBL
      Q9D3L3
      Conserved Domains (3) summary
      cd15884
      Location:159 → 217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100 → 157
      SNAP-25; SNAP-25 family

    2. XM_006499054.5 → XP_006499117.1  synaptosomal-associated protein 23 isoform X1

      See identical proteins and their annotated locations for XP_006499117.1

      UniProtKB/TrEMBL
      Q9D3L3
      Conserved Domains (3) summary
      cd15884
      Location:159 → 217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:9 → 75
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100 → 157
      SNAP-25; SNAP-25 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09044.1 GenPept UniProtKB/Swiss-Prot:O09044

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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