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    Mdp1 magnesium-dependent phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67881, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mdp1provided by MGI
    Official Full Name
    magnesium-dependent phosphatase 1provided by MGI
    Primary source
    MGI:MGI:1915131
    See related
    Ensembl:ENSMUSG00000002329 AllianceGenome:MGI:1915131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810034K20Rik
    Summary
    Predicted to enable acid phosphatase activity. Predicted to be involved in fructosamine metabolic process. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human MDP1 (magnesium dependent phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.3), large intestine adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C3; 14 28.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55895346..55897908, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55657889..55660451, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene importin 4 Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4 Neighboring gene neural precursor cell expressed, developmentally down-regulated gene 8 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene Terf1 (TRF1)-interacting nuclear factor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56300752-56300861

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Peisach E, et al. Biochemistry, 2004 Oct 12. PMID 15461449
    2. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. Selengut JD, et al. Biochemistry, 2000 Jul 18. PMID 10889041
    3. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    4. MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases. Selengut JD. Biochemistry, 2001 Oct 23. PMID 11601995
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. X ray crystallography of MDP-1
      Title: X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    magnesium-dependent phosphatase 1
    Names
    MDP-1
    NP_075886.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023397.5 → NP_075886.1  magnesium-dependent phosphatase 1

      See identical proteins and their annotated locations for NP_075886.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AI846874, AK007319, BC046613
      Consensus CDS
      CCDS27123.1
      UniProtKB/Swiss-Prot
      Q9D967
      Related
      ENSMUSP00000002400.7, ENSMUST00000002400.7
      Conserved Domains (1) summary
      pfam12689
      Location:3 → 160
      Acid_PPase; Acid Phosphatase

    RNA

    1. NR_028316.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) retains an intron that results in a frameshift, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI846874, AK007694, BC046613
      Related
      ENSMUST00000226659.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55895346..55897908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D967.1 GenPept UniProtKB/Swiss-Prot:Q9D967

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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