Prxl2c peroxiredoxin like 2C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prxl2cprovided by MGI
Official Full Name: peroxiredoxin like 2Cprovided by MGI
Primary source: MGI:MGI:1913379
See related: Ensembl:ENSMUSG00000021482 AllianceGenome:MGI:1913379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aaed1; 1110018J18Rik
Summary: Predicted to enable antioxidant activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. Orthologous to human PRXL2C (peroxiredoxin like 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 20.0), liver adult (RPKM 19.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B3; 13 33.26 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (64437612..64460524, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (64289798..64312710, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490561

AI849003 (e-PCR)
- UniSTS:165879

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: peroxiredoxin-like 2C

Names: AhpC/TSA antioxidant enzyme domain containing 1; UPF0308 protein C9orf21 homolog; ahpC/TSA antioxidant enzyme domain-containing protein 1; thioredoxin-like protein AAED1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025370.3 → NP_079646.1 peroxiredoxin-like 2C

See identical proteins and their annotated locations for NP_079646.1

Status: VALIDATED

Source sequence(s)

AK003782, AK145867, AK168701, CT030159

Consensus CDS

CCDS26599.1

UniProtKB/Swiss-Prot

Q3UFP2, Q9CVT8, Q9D1A0

UniProtKB/TrEMBL

Q3TGK4

Related

ENSMUSP00000152323.2, ENSMUST00000222570.2

Conserved Domains (1) summary

cd02970
Location:34 → 195

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...