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    Cgnl1 cingulin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 68178, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Cgnl1provided by MGI
    Official Full Name
    cingulin-like 1provided by MGI
    Primary source
    MGI:MGI:1915428
    See related
    Ensembl:ENSMUSG00000032232 AllianceGenome:MGI:1915428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jacop; 4933421H10Rik; 9930020M10Rik
    Summary
    This gene encodes a protein localized to the tight junctions and adherens junctions in vertebrate epithelial cells. The encoded protein regulates the activity of Rho family GTPases during junction assembly and at confluence. At the adherens junctions, the encoded protein is part of a protein complex that links E-cadherin to the microtubule cytoskeleton. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Broad expression in kidney adult (RPKM 30.5), placenta adult (RPKM 10.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 D; 9 39.85 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71533789..71716582, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71626507..71809300, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71454614-71454767 Neighboring gene STARR-seq mESC enhancer starr_24576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71471793-71471976 Neighboring gene STARR-seq mESC enhancer starr_24577 Neighboring gene MAD1 mitotic arrest deficient 1-like 1 pseudogene Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene STARR-positive B cell enhancer mm9_chr9:71493898-71494198 Neighboring gene predicted gene, 51713 Neighboring gene STARR-seq mESC enhancer starr_24580 Neighboring gene STARR-seq mESC enhancer starr_24581 Neighboring gene STARR-seq mESC enhancer starr_24582 Neighboring gene STARR-seq mESC enhancer starr_24583 Neighboring gene transcription factor 12 Neighboring gene STARR-positive B cell enhancer ABC_E2904 Neighboring gene splicing factor, arginine/serine-rich 7 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:71799166-71799467 Neighboring gene STARR-positive B cell enhancer mm9_chr9:71823828-71824128 Neighboring gene ribosomal protein L15, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex. Citi S, et al. Ann N Y Acad Sci, 2012 Jun. PMID 22671598
    2. Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization. Flinois A, et al. J Cell Sci, 2024 Mar 1. PMID 37013686, Free PMC Article
    3. Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis. Chrifi I, et al. Cardiovasc Res, 2017 Dec 1. PMID 29016873, Free PMC Article
    4. JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. Ohnishi H, et al. J Biol Chem, 2004 Oct 29. PMID 15292197
    5. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization.
      Title: Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization.
    2. demonstrate a functional relevance for cingulin-like 1 as a defining factor in new vessel formation both in vitro and in vivo
      Title: Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis.
    3. JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons.
      Title: JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cingulin-like protein 1
    Names
    junction-associated coiled-coil protein
    paracingulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304362.2 → NP_001291291.1  cingulin-like protein 1

      See identical proteins and their annotated locations for NP_001291291.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093483, AC107662
      Consensus CDS
      CCDS23328.1
      UniProtKB/Swiss-Prot
      B2RSU6, Q5U5U0, Q69ZB4, Q6AW69, Q8BLZ5, Q8BZ26, Q9D2T3
      UniProtKB/TrEMBL
      B2RY19
      Related
      ENSMUSP00000112479.2, ENSMUST00000122065.2
      Conserved Domains (1) summary
      pfam01576
      Location:611 → 1253
      Myosin_tail_1; Myosin tail

    2. NM_001407857.1 → NP_001394786.1  cingulin-like protein 1

      Status: REVIEWED

      Source sequence(s)
      AC107662
      UniProtKB/Swiss-Prot
      B2RSU6, Q5U5U0, Q69ZB4, Q6AW69, Q8BLZ5, Q8BZ26, Q9D2T3

    3. NM_026599.6 → NP_080875.3  cingulin-like protein 1

      See identical proteins and their annotated locations for NP_080875.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093483, AC107662
      Consensus CDS
      CCDS23328.1
      UniProtKB/Swiss-Prot
      B2RSU6, Q5U5U0, Q69ZB4, Q6AW69, Q8BLZ5, Q8BZ26, Q9D2T3
      UniProtKB/TrEMBL
      B2RY19
      Related
      ENSMUSP00000072672.3, ENSMUST00000072899.9
      Conserved Domains (1) summary
      pfam01576
      Location:611 → 1253
      Myosin_tail_1; Myosin tail

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      71533789..71716582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511395.1 → XP_006511458.1  cingulin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006511458.1

      UniProtKB/Swiss-Prot
      B2RSU6, Q5U5U0, Q69ZB4, Q6AW69, Q8BLZ5, Q8BZ26, Q9D2T3
      UniProtKB/TrEMBL
      B2RY19
      Conserved Domains (1) summary
      pfam01576
      Location:611 → 1253
      Myosin_tail_1; Myosin tail
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AW69.3 GenPept UniProtKB/Swiss-Prot:Q6AW69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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