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    Recql5 RecQ protein-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 170472, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Recql5provided by MGI
    Official Full Name
    RecQ protein-like 5provided by MGI
    Primary source
    MGI:MGI:2156841
    See related
    Ensembl:ENSMUSG00000020752 AllianceGenome:MGI:2156841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RecQ5; Recq5b; Recql5b
    Summary
    Predicted to enable DNA helicase activity; RNA polymerase II complex binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cellular response to camptothecin; negative regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II, holoenzyme. Predicted to be active in chromosome and cytoplasm. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.0), large intestine adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 80.91 cM; 11 E2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115783421..115824339, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115892595..115933514, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3039 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene STARR-seq mESC enhancer starr_31175 Neighboring gene STARR-seq mESC enhancer starr_31178 Neighboring gene LLGL2 scribble cell polarity complex component Neighboring gene myosin XVB Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115759828-115760025 Neighboring gene small integral membrane protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E1850 Neighboring gene small integral membrane protein 6 Neighboring gene STARR-seq mESC enhancer starr_31180 Neighboring gene STARR-seq mESC enhancer starr_31181 Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene STARR-seq mESC enhancer starr_31187 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene integrin beta 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice. Liao WQ, et al. World J Gastroenterol, 2015 Sep 28. PMID 26420964, Free PMC Article
    2. Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment. Hu Y, et al. Mol Biol Cell, 2009 Jan. PMID 18987339, Free PMC Article
    3. Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Hu Y, et al. Mol Cell Biol, 2005 May. PMID 15831450, Free PMC Article
    4. Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta. Ohhata T, et al. Gene, 2001 Dec 12. PMID 11738818
    5. Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice. Hu Y, et al. World J Gastroenterol, 2010 Mar 28. PMID 20333788, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recql5 protects the liver against LPS/D-Gal-induced injury by suppressing hepatocyte apoptosis and oxidative stress and modulation of CYP450 expression.
      Title: Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice.
    2. Recql5 has a tumor suppressor role in the gastrointestinal tract of Apc(min) mice.
      Title: Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice.
    3. Data suggest that Recql5 helps maintain active DNA replication to prevent collapse of replication forks and accumulation of DSBs, preserve genome integrity and prevent cell death after replication stress due to topoisomerase I poisoning.
      Title: Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment.
    4. Recql5-deficient cells exhibit elevated frequencies of spontaneous DNA double-strand breaks and homologous recombination (
      Title: RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to camptothecin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to camptothecin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase Q5
    Names
    DNA 3'-5' helicase RecQ5
    DNA helicase, RecQ-like type 5
    RECQL5beta
    NP_569721.1
    XP_006532421.1
    XP_006532422.1
    XP_006532424.1
    XP_006532425.1
    XP_006532426.1
    XP_030101474.1
    XP_036012259.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130454.2 → NP_569721.1  ATP-dependent DNA helicase Q5

      See identical proteins and their annotated locations for NP_569721.1

      Status: VALIDATED

      Source sequence(s)
      AK049269, AL645647, AW049927, BC059000
      Consensus CDS
      CCDS25650.1
      UniProtKB/Swiss-Prot
      Q8BQD7, Q8C7T6, Q8VID3, Q8VID5
      Related
      ENSMUSP00000021097.4, ENSMUST00000021097.10
      Conserved Domains (2) summary
      COG0514
      Location:15 → 439
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:626 → 817
      RecQ5; RecQ helicase protein-like 5 (RecQ5)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115783421..115824339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532361.5 → XP_006532424.1  ATP-dependent DNA helicase Q5 isoform X4

      See identical proteins and their annotated locations for XP_006532424.1

      Conserved Domains (2) summary
      COG0514
      Location:1 → 133
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:320 → 508
      RecQ5; RecQ helicase protein-like 5 (RecQ5)

    2. XM_006532359.5 → XP_006532422.1  ATP-dependent DNA helicase Q5 isoform X3

      Conserved Domains (2) summary
      COG0514
      Location:6 → 398
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:585 → 773
      RecQ5; RecQ helicase protein-like 5 (RecQ5)

    3. XM_006532358.5 → XP_006532421.1  ATP-dependent DNA helicase Q5 isoform X1

      Conserved Domains (2) summary
      COG0514
      Location:16 → 440
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:627 → 815
      RecQ5; RecQ helicase protein-like 5 (RecQ5)

    4. XM_036156366.1 → XP_036012259.1  ATP-dependent DNA helicase Q5 isoform X2

      UniProtKB/Swiss-Prot
      Q8BQD7, Q8C7T6, Q8VID3, Q8VID5
      Conserved Domains (2) summary
      COG0514
      Location:15 → 439
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:626 → 817
      RecQ5; RecQ helicase protein-like 5 (RecQ5)

    5. XM_006532363.5 → XP_006532426.1  ATP-dependent DNA helicase Q5 isoform X6

      Conserved Domains (2) summary
      pfam06959
      Location:231 → 419
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:17 → 40
      RecQ_Zn_bind; RecQ zinc-binding

    6. XM_006532362.4 → XP_006532425.1  ATP-dependent DNA helicase Q5 isoform X5

      Conserved Domains (2) summary
      pfam06959
      Location:231 → 419
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:12 → 40
      RecQ_Zn_bind; RecQ zinc-binding

    7. XM_030245614.2 → XP_030101474.1  ATP-dependent DNA helicase Q5 isoform X7

      Conserved Domains (1) summary
      COG0514
      Location:16 → 440
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

    RNA

    1. XR_003949325.2 RNA Sequence

    2. XR_003949327.2 RNA Sequence

    3. XR_003949326.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VID5.1 GenPept UniProtKB/Swiss-Prot:Q8VID5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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