Bmp5 bone morphogenetic protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmp5provided by MGI
Official Full Name: bone morphogenetic protein 5provided by MGI
Primary source: MGI:MGI:88181
See related: Ensembl:ENSMUSG00000032179 AllianceGenome:MGI:88181
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: se
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Mice with null mutations in this gene exhibit a short ear phenotype, which is characterized by reduced size of the external ear, altered size and shape of the sternum, and other skeletal and soft-tissue abnormalities. [provided by RefSeq, Jul 2016]
Expression: Biased expression in bladder adult (RPKM 8.5), lung adult (RPKM 3.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 42.34 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (75682647..75807598)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (75775365..75900316)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice.
Title: BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice.
Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis.
Title: Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis.
Changes in the Long Noncoding RNA Expression Profile in the Development of the Embryonic External Ear After BMP5 Gene Mutation.
Title: Changes in the Long Noncoding RNA Expression Profile in the Development of the Embryonic External Ear After BMP5 Gene Mutation.
Changes in the Transcriptome-Associated Co-Expression Profile of Embryonic External Ear Development After the BMP5 Gene Mutation.
Title: Changes in the Transcriptome-Associated Co-Expression Profile of Embryonic External Ear Development After the BMP5 Gene Mutation.
Bmp5 Mutation Alters mRNA Expression During External Ear Development.
Title: Bmp5 Mutation Alters mRNA Expression During External Ear Development.
BMP5 ameliorates diabetic peripheral neuropathy by augmenting mitochondrial function and inhibiting apoptosis in Schwann cells.
Title: BMP5 ameliorates diabetic peripheral neuropathy by augmenting mitochondrial function and inhibiting apoptosis in Schwann cells.
Bmp5 Mutation Alters miRNA Expression During Embryonic External Ear Development.
Title: Bmp5 Mutation Alters miRNA Expression During Embryonic External Ear Development.
Bmp5 Mutation Alters circRNA Expression During Embryonic External Ear Development.
Title: Bmp5 Mutation Alters circRNA Expression During Embryonic External Ear Development.
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Title: BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Data conclude that BMP-5 has stage-specific role to play during MC3T3E1 osteoblast differentiation in part by autocrine p38/Runx2/COLIA1 signaling.
Title: Bone morphogenetic protein-5, a key molecule that mediates differentiation in MC3T3E1 osteoblast cell line.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (6) 1 citation
Chemically induced (other) (2) 1 citation
Radiation induced (15) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:496642 (e-PCR)
- UniSTS:496642

Bmp5 (e-PCR), detects polymorphism
- UniSTS:496642

AU023399 (e-PCR)
- UniSTS:165648

Bmp5 (e-PCR), detects polymorphism
- UniSTS:532294

NoName (e-PCR)
- UniSTS:489036

26.MMHAP76FRA11.seq (e-PCR)
- UniSTS:123754

Bmp5 (e-PCR), detects polymorphism
- UniSTS:474743

NoName (e-PCR)
- UniSTS:236197

PMC56999P1 (e-PCR)
- UniSTS:273363

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in allantois development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior head development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chorio-allantoic fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardial cushion formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart trabecula morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hindbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within male genitalia development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in neural fold elevation formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pharyngeal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type B pancreatic cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bone morphogenetic protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007555.4 → NP_031581.2 bone morphogenetic protein 5 preproprotein

See identical proteins and their annotated locations for NP_031581.2

Status: REVIEWED

Source sequence(s)

AC079245, AK033362, AK135704

Consensus CDS

CCDS23348.1

UniProtKB/TrEMBL

Q496P8

Related

ENSMUSP00000012281.8, ENSMUST00000012281.8

Conserved Domains (2) summary

pfam00019
Location:351 → 453

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:31 → 304

TGFb_propeptide; TGF-beta propeptide