Zic2 zinc finger protein of the cerebellum 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zic2provided by MGI
Official Full Name: zinc finger protein of the cerebellum 2provided by MGI
Primary source: MGI:MGI:106679
See related: Ensembl:ENSMUSG00000061524 AllianceGenome:MGI:106679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ku; HPE5
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in regulation of transcription, DNA-templated; retinal ganglion cell axon guidance; and visual perception. Acts upstream of or within several processes, including cilium organization; nervous system development; and positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; eye; and neural ectoderm. Used to study holoprosencephaly 5 and schizophrenia. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 37.4), whole brain E14.5 (RPKM 15.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E5; 14 65.97 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (122712796..122717740)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (122475384..122480328)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.
Title: SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.
Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2.
Title: Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2.
ZIC2 is required for correct Nodal expression at the node and suggest a model in which ZIC2 acts at different levels to establish LR asymmetry, promoting both the production of the signal that induces left side identity and the morphogenesis of the cilia that bias its distribution.
Title: A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.
Zic2 mutations significantly reduced trabecular bone mass and distal tibial cortical thickness.
Title: Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.
Loss of ZIC2 expression is associated with holoprosencephaly.
Title: Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.
The major acting transcription factors shift from SOX2/POU5F1 in mouse ESCs to ZIC2/OTX2 in EpiSCs, and this shift is primed in ESCs by binding of ZIC2 at relevant genomic positions that later function as enhancers.
Title: Roles of ZIC2 in Regulation of Pluripotent Stem Cells.
Zic2 and Zic1 proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.
Title: Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice and C. elegans.
This shift in the major acting transcription factors appears to be primed by binding of ZIC2 in embryonic stem cells at relevant genomic positions.
Title: ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network.
Here, we reveal a previously unknown role for Zic2 in the migration of forebrain neurons such as Cajal-Retzius cells, interneurons moving to the ventral lateral geniculate nucleus, and neocortical cells going to the amygdala.
Title: Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain.
Zic1 and Zic2 are required for coordinating mature neuronal gene expression patterns.
Title: Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB391594 (e-PCR)
- UniSTS:208678

NoName (e-PCR)
- UniSTS:548440

NoName (e-PCR)
- UniSTS:494168

UniSTS:496749 (e-PCR)
- UniSTS:496749

Zic2 (e-PCR), detects polymorphism
- UniSTS:496749

UniSTS:496750 (e-PCR)
- UniSTS:496750

Zic5 (e-PCR), detects polymorphism
- UniSTS:496750

D70848 (e-PCR)
- UniSTS:186016

UniSTS:466092 (e-PCR)
- UniSTS:466092

Zic2 (e-PCR), detects polymorphism
- UniSTS:466092

Zic2 (e-PCR), detects polymorphism
- UniSTS:144840

UniSTS:144841 (e-PCR)
- UniSTS:144841

Zic2 (e-PCR), detects polymorphism
- UniSTS:144841

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axial mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in central nervous system segmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural plate development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nodal signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in paraxial mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein ZIC 2

Names: GENA 29; Zic family member 2 (odd-paired homolog, Drosophila); kumba; odd-paired homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009574.3 → NP_033600.3 zinc finger protein ZIC 2

See identical proteins and their annotated locations for NP_033600.3

Status: VALIDATED

Source sequence(s)

AC154683, AK161979, BB655427, BE988982

Consensus CDS

CCDS27349.1

UniProtKB/Swiss-Prot

Q62520

UniProtKB/TrEMBL

F8VPV3

Related

ENSMUSP00000075283.6, ENSMUST00000075888.6

Conserved Domains (3) summary

COG5189
Location:328 → 412

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:306 → 326

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam18366
Location:249 → 294

zf_ZIC; Zic proteins zinc finger domain