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    Calcb calcitonin-related polypeptide, beta [ Mus musculus (house mouse) ]

    Gene ID: 116903, updated on 27-Feb-2024

    Summary

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    Official Symbol
    Calcbprovided by MGI
    Official Full Name
    calcitonin-related polypeptide, betaprovided by MGI
    Primary source
    MGI:MGI:2151254
    See related
    Ensembl:ENSMUSG00000030666 AllianceGenome:MGI:2151254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGRP2; Calc2
    Summary
    Predicted to enable calcitonin receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cytosolic calcium ion concentration. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human CALCB (calcitonin related polypeptide beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 2.1), large intestine adult (RPKM 0.5) and 13 other tissues See more
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    Genomic context

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    Location:
    7 F1; 7 60.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (114315790..114322603)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114716555..114723368)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19935 Neighboring gene STARR-seq mESC enhancer starr_19936 Neighboring gene INSC spindle orientation adaptor protein Neighboring gene STARR-seq mESC enhancer starr_19937 Neighboring gene predicted gene, 24982 Neighboring gene STARR-seq mESC enhancer starr_19938 Neighboring gene ribosomal protein S4-like, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of calcitonin gene-related peptide in functional adaptation of the skeleton. Sample SJ, et al. PLoS One, 2014. PMID 25536054, Free PMC Article
    2. Pre-symptomatic alterations in subcellular betaCGRP distribution in motor neurons precede astrogliosis in ALS mice. Ringer C, et al. Neurobiol Dis, 2009 Aug. PMID 19465128
    3. alphaCGRP and betaCGRP transcript amount in mouse tissues of various developmental stages and their tissue expression sites. Rezaeian AH, et al. Brain Dev, 2009 Oct. PMID 19062206
    4. Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis. Thompson BJ, et al. Dig Dis Sci, 2008 Jan. PMID 17530400
    5. Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes. Thomas PM, et al. DNA Seq, 2001. PMID 11761712

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. activation of periosteal mineralizing surfaces in response to mechanical loading of bone is CGRPalpha-dependent in vivo.
      Title: Role of calcitonin gene-related peptide in functional adaptation of the skeleton.
    2. gene expression of calcitonin gene-related peptide beta in mouse brain, liver, kidney, heart, & testis at embryonic day 14, 17, postnatal day 1, 7, and adult. found mainly in brain. one expression peak at E17, the other at P7. also C cells of e17 thyroid.
      Title: alphaCGRP and betaCGRP transcript amount in mouse tissues of various developmental stages and their tissue expression sites.
    3. A close association of betaCGRP-containing dysmorphic dendritic structures with processes of activated astrocytes suggests that betaCGRP may function as a motor neuron-derived signaling molecule for astrocyte activation in amyotrophic lateral sclerosis
      Title: Pre-symptomatic alterations in subcellular betaCGRP distribution in motor neurons precede astrogliosis in ALS mice.
    4. These results indicate that CGRP signaling through CLR/RAMP1 receptors plays a crucial role in the regulation of both blood pressure by vascular relaxation and proinflammatory cytokine production from dendritic cells.
      Title: Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (6) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130530

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcitonin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcitonin gene-related peptide 2
    Names
    CGRP-II
    beta-type CGRP
    calcitonin gene-related peptide II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054084.2 → NP_473425.2  calcitonin gene-related peptide 2 precursor

      See identical proteins and their annotated locations for NP_473425.2

      Status: VALIDATED

      Source sequence(s)
      AI324836, BC111865
      Consensus CDS
      CCDS21764.1
      UniProtKB/Swiss-Prot
      Q99MP3
      UniProtKB/TrEMBL
      Q3UW96
      Related
      ENSMUSP00000032902.5, ENSMUST00000032902.11
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 125
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      114315790..114322603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507212.4 → XP_006507275.1  calcitonin gene-related peptide 2 isoform X1

      See identical proteins and their annotated locations for XP_006507275.1

      UniProtKB/Swiss-Prot
      Q99MP3
      UniProtKB/TrEMBL
      Q3UW96
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 125
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    2. XM_006507213.4 → XP_006507276.1  calcitonin gene-related peptide 2 isoform X1

      See identical proteins and their annotated locations for XP_006507276.1

      UniProtKB/Swiss-Prot
      Q99MP3
      UniProtKB/TrEMBL
      Q3UW96
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 125
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MP3.1 GenPept UniProtKB/Swiss-Prot:Q99MP3

    Gene LinkOut

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