H1f0 H1.0 linker histone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H1f0provided by MGI
Official Full Name: H1.0 linker histoneprovided by MGI
Primary source: MGI:MGI:95893
See related: Ensembl:ENSMUSG00000096210 AllianceGenome:MGI:95893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H1-0; H1fv; H1(0); D130017D06Rik
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78912412..78914704)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79028212..79030504)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
Title: Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Title: Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Computation of FRAP recovery times for linker histone - chromatin binding on the basis of Brownian dynamics simulations.
Title: Computation of FRAP recovery times for linker histone - chromatin binding on the basis of Brownian dynamics simulations.
mild overexpression of H1.0 did not alter MeCP2 binding, suggesting that the functional binding of MeCP2 and H1.0 are largely independent
Title: Genome-wide distribution of linker histone H1.0 is independent of MeCP2.
Marked reduction in total H1 levels causes significant reduction in both expression and the level of active histone mark H3K4me3 at many Hox genes.
Title: Reduction of Hox gene expression by histone H1 depletion.
both P-TEFb activity and H1 phosphorylation are necessary for the full differentiation of C2C12 myoblasts into myotubes.
Title: Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation.
Histone H1 poly[ADP]-ribosylation of proteins over a specific time course is required for the changes in synaptic plasticity related to memory stabilization in mice.
Title: Histone H1 poly[ADP]-ribosylation regulates the chromatin alterations required for learning consolidation.
H1 dephosphorylation and H2A.X hyperphosphorylation are necessary steps on the apoptotic pathway.
Title: Hyperphosphorylation of histone H2A.X and dephosphorylation of histone H1 subtypes in the course of apoptosis.
Analysis of DNA-induced secondary structure of the carboxyl-terminal domain of histone H1 subtypes H1(0)(C-H1(0)) and H1t (C-H1t).
Title: DNA-induced secondary structure of the carboxyl-terminal domain of histone H1.
H1 isoforms H1.0, H1.1, and H1.2 are non-responsive to hormone whereas prolonged dexamethasone treatment effectively dephosphorylated the H1.3, H1.4, and H1.5 isoforms
Title: Hormone-mediated dephosphorylation of specific histone H1 isoforms.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC164858P4 (e-PCR)
- UniSTS:271530

H1f0 (e-PCR), detects polymorphism
- UniSTS:526007

H1f0 (e-PCR), detects polymorphism
- UniSTS:143298

U18295 (e-PCR)
- UniSTS:186317

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	EXP Inferred from Experiment more info	PubMed
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of euchromatin	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H1.0

Names: H1 histone family, member 0; H1-0 histone; histone H1'; histone H1(0); myD196

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.