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    Nkiras2 NFKB inhibitor interacting Ras-like protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 71966, updated on 8-Mar-2024

    Summary

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    Official Symbol
    Nkiras2provided by MGI
    Official Full Name
    NFKB inhibitor interacting Ras-like protein 2provided by MGI
    Primary source
    MGI:MGI:1919216
    See related
    Ensembl:ENSMUSG00000017837 AllianceGenome:MGI:1919216
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KBRAS2; 2410003M04Rik; 4930527H08Rik; D630018G21Rik
    Summary
    Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. Is expressed in cerebral cortex; dorsal root ganglion; and nose. Orthologous to human NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 90.6), colon adult (RPKM 42.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 63.47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100510007..100518436)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100619181..100627610)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5277 Neighboring gene outer dynein arm complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E8995 Neighboring gene STARR-positive B cell enhancer ABC_E7060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100443371-100443554 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene STARR-positive B cell enhancer ABC_E4000 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene STARR-positive B cell enhancer ABC_E2369 Neighboring gene STARR-positive B cell enhancer ABC_E7062 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene DExH-box helicase 58

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors. Tago K, et al. Sci Rep, 2021 Oct 19. PMID 34667224, Free PMC Article
    2. κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. Beel S, et al. Nat Commun, 2020 Jul 8. PMID 32641778, Free PMC Article
    3. KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. Tago K, et al. J Biol Chem, 2010 Oct 1. PMID 20639196, Free PMC Article
    4. RelA/p65 regulation of IkappaBbeta. Hertlein E, et al. Mol Cell Biol, 2005 Jun. PMID 15923614, Free PMC Article
    5. κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation. Oeckinghaus A, et al. Cell Rep, 2014 Sep 25. PMID 25220458, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.
      Title: K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.
    2. KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.
      Title: KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activating protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ral protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Ral protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung alveolus development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within surfactant homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NF-kappa-B inhibitor-interacting Ras-like protein 2
    Names
    I-kappa-B-interacting Ras-like protein 2
    kappa B-Ras protein 2
    kappaB-Ras2
    NP_082300.1
    XP_030102201.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028024.2 → NP_082300.1  NF-kappa-B inhibitor-interacting Ras-like protein 2

      See identical proteins and their annotated locations for NP_082300.1

      Status: PROVISIONAL

      Source sequence(s)
      AL591469
      Consensus CDS
      CCDS25429.1
      UniProtKB/Swiss-Prot
      Q8BWG0, Q9CR56
      UniProtKB/TrEMBL
      F6XZA4
      Related
      ENSMUSP00000017981.4, ENSMUST00000017981.10
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100510007..100518436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246341.1 → XP_030102201.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BWG0, Q9CR56
      UniProtKB/TrEMBL
      F6XZA4
      Related
      ENSMUSP00000059559.4, ENSMUST00000051947.10
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR56.1 GenPept UniProtKB/Swiss-Prot:Q9CR56

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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