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    Spdl1 spindle apparatus coiled-coil protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 70385, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Spdl1provided by MGI
    Official Full Name
    spindle apparatus coiled-coil protein 1provided by MGI
    Primary source
    MGI:MGI:1917635
    See related
    Ensembl:ENSMUSG00000069910 AllianceGenome:MGI:1917635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc99; 1700018I02Rik; 2600001J17Rik; 2810049B11Rik
    Summary
    Predicted to enable enzyme binding activity and kinetochore binding activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase plate congression; and protein localization to kinetochore. Predicted to act upstream of or within cell division. Predicted to be located in nucleus. Predicted to be part of outer kinetochore. Predicted to be active in spindle pole. Is expressed in several structures, including alimentary system; axial musculature; brain; liver lobe; and maturing glomerular tuft. Orthologous to human SPDL1 (spindle apparatus coiled-coil protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 8.5), liver E14 (RPKM 7.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A4; 11 19.9 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (34700012..34724492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (34809185..34833665, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dedicator of cyto-kinesis 2 Neighboring gene predicted gene, 51858 Neighboring gene STARR-seq mESC enhancer starr_29152 Neighboring gene STARR-positive B cell enhancer ABC_E5215 Neighboring gene STARR-positive B cell enhancer ABC_E2983 Neighboring gene STARR-seq mESC enhancer starr_29153 Neighboring gene predicted gene, 53681 Neighboring gene STARR-positive B cell enhancer ABC_E3939 Neighboring gene predicted gene, 22022 Neighboring gene predicted gene, 25799

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localization and function of mSpindly during mouse oocyte meiotic maturation. Zhang QH, et al. Cell Cycle, 2010 Jun 1. PMID 20505367
    2. MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM. Kodama T, et al. Proc Natl Acad Sci U S A, 2019 Nov 19. PMID 31690663, Free PMC Article
    3. The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart. Taliani V, et al. Elife, 2023 Mar 6. PMID 36877136, Free PMC Article
    4. Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. Zhou L, et al. FASEB J, 2017 Jan. PMID 27694478, Free PMC Article
    5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spdl1 expression is significantly down-regulated in Mrtfb knockout mouse intestine.
      Title: MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.
    2. Overexpression of mSpindly failed to enhance inactivation of SAC and acceleration of the meiotic process.
      Title: Localization and function of mSpindly during mouse oocyte meiotic maturation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinetochore binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinetochore binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Spindly
    Names
    coiled-coil domain containing 99
    coiled-coil domain-containing protein 99
    spindle apparatus coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027411.2 → NP_081687.2  protein Spindly

      See identical proteins and their annotated locations for NP_081687.2

      Status: VALIDATED

      Source sequence(s)
      AK139553, AK160143, BY712013, DV663229
      Consensus CDS
      CCDS24541.1
      UniProtKB/Swiss-Prot
      Q5DY45, Q923A2
      Related
      ENSMUSP00000090882.3, ENSMUST00000093191.3
      Conserved Domains (1) summary
      COG1196
      Location:1 → 344
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      34700012..34724492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534169.3 → XP_006534232.1  protein Spindly isoform X1

      See identical proteins and their annotated locations for XP_006534232.1

      UniProtKB/Swiss-Prot
      Q5DY45, Q923A2
      Conserved Domains (1) summary
      COG1196
      Location:1 → 344
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_036156979.1 → XP_036012872.1  protein Spindly isoform X3

      Conserved Domains (1) summary
      TIGR02168
      Location:2 → 281
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_011249245.3 → XP_011247547.1  protein Spindly isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:18 → 283
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923A2.2 GenPept UniProtKB/Swiss-Prot:Q923A2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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