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    Adgre4 adhesion G protein-coupled receptor E4 [ Mus musculus (house mouse) ]

    Gene ID: 52614, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adgre4provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor E4provided by MGI
    Primary source
    MGI:MGI:1196464
    See related
    Ensembl:ENSMUSG00000032915 AllianceGenome:MGI:1196464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emr4; Fire; Gpr127; Egf-tm7; D17Ertd479e
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Located in cell surface. Is expressed in alimentary system; gonad; and metanephros. Orthologous to several human genes including ADGRE3 (adhesion G protein-coupled receptor E3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 6.8), lung adult (RPKM 1.5) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 D; 17 28.98 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56056984..56160662)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55749984..55853662)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protection of telomeres 1B Neighboring gene predicted gene, 54013 Neighboring gene STARR-positive B cell enhancer ABC_E5620 Neighboring gene coiled-coil domain containing 77 pseudogene Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42870 Neighboring gene STARR-seq mESC enhancer starr_42871 Neighboring gene vomeronasal 2, receptor 121 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42872 Neighboring gene zinc finger protein 119a Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene zinc finger protein 959

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of F4/80-like-receptor, a seven-span membrane protein expressed differentially by dendritic cell and monocyte-macrophage subpopulations. Caminschi I, et al. J Immunol, 2001 Oct 1. PMID 11564768
    2. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. Caminschi I, et al. DNA Seq, 2006 Feb. PMID 16753812
    3. Different mechanisms of syndecan-1 activation through a fibroblast-growth-factor-inducible response element (FiRE) in mucosal and cutaneous wounds. Rautava J, et al. J Dent Res, 2003 May. PMID 12709506
    4. EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20. Stacey M, et al. J Biol Chem, 2002 Aug 9. PMID 12023293
    5. Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. Ring HZ, et al. Genomics, 1999 Mar 15. PMID 10087204

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two alternatively spliced human FIRE transcripts were identified, neither are predicted to express the TM7 cassette. Thus, if the human FIRE exists, it is likely to be expressed as a soluble secreted molecule.
      Title: Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE.
    2. activated in mucosal [and cutaneous]wounds
      Title: Different mechanisms of syndecan-1 activation through a fibroblast-growth-factor-inducible response element (FiRE) in mucosal and cutaneous wounds.
    3. the first EGF-TM7 receptor known to mediate the cellular interaction between myeloid cells and B cells
      Title: EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor E4
    Names
    EGF-like module containing, mucin-like, hormone receptor-like sequence 4
    EGF-like module receptor 4
    EGF-like module-containing mucin-like hormone receptor-like 4
    F4/80-like-receptor
    seven-span membrane protein FIRE

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139138.3 → NP_631877.2  adhesion G protein-coupled receptor E4 precursor

      See identical proteins and their annotated locations for NP_631877.2

      Status: VALIDATED

      Source sequence(s)
      AF396935, AK036459, AK037483, CT573084
      Consensus CDS
      CCDS50148.1
      UniProtKB/Swiss-Prot
      Q3U1I7, Q8BYX0, Q8VIM3, Q91ZE5
      UniProtKB/TrEMBL
      Q0VBQ8
      Related
      ENSMUSP00000025004.7, ENSMUST00000025004.7
      Conserved Domains (4) summary
      smart00179
      Location:77 → 105
      EGF_CA; Calcium-binding EGF-like domain
      pfam01825
      Location:290 → 332
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:214 → 262
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:343 → 588
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56056984..56160662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZE5.1 GenPept UniProtKB/Swiss-Prot:Q91ZE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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