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    H2-Ab1 histocompatibility 2, class II antigen A, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 14961, updated on 17-Jun-2021

    Summary

    Official Symbol
    H2-Ab1provided by MGI
    Official Full Name
    histocompatibility 2, class II antigen A, beta 1provided by MGI
    Primary source
    MGI:MGI:103070
    See related
    Ensembl:ENSMUSG00000073421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I; Ia; Abe; IAb; Ia2; Rmc; H-2A; H2-A; I-A<; I-Ab; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; H2-Ab_; I-Abeta; AI845868
    Expression
    Biased expression in spleen adult (RPKM 2279.6), large intestine adult (RPKM 1316.2) and 12 other tissues See more
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    Genomic context

    See H2-Ab1 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34482201..34488392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34263227..34269418)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34400172..34406363)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, O region beta locus Neighboring gene predicted gene 20506 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene histocompatibility 2, class II antigen E beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein antigen binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables toxic substance binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell affinity maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of peptide antigen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in humoral immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 1 type immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of alpha-beta T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of alpha-beta T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of alpha-beta T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MHC class II protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histocompatibility 2, class II antigen A, beta 1
    Names
    H-2 class II histocompatibility antigen, A beta chain
    MHC class II H2-IA-beta-psi
    histocompatibility 2, class II antigen A, beta, promoter 1
    major histocompatibility complex class II beta chain
    response to metastatic cancers 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207105.3NP_996988.2  histocompatibility 2, class II antigen A, beta 1 precursor

      See identical proteins and their annotated locations for NP_996988.2

      Status: VALIDATED

      Source sequence(s)
      AK077436, BB056841, BY205244, CK330363
      Consensus CDS
      CCDS37583.1
      UniProtKB/Swiss-Prot
      P14483
      UniProtKB/TrEMBL
      Q3TD53, Q8BPA0
      Related
      ENSMUSP00000041008.6, ENSMUST00000040828.7
      Conserved Domains (2) summary
      cd05766
      Location:125218
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      pfam00969
      Location:40111
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34482201..34488392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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