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    Zfp352 zinc finger protein 352 [ Mus musculus (house mouse) ]

    Gene ID: 236537, updated on 16-Mar-2024

    Summary

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    Official Symbol
    Zfp352provided by MGI
    Official Full Name
    zinc finger protein 352provided by MGI
    Primary source
    MGI:MGI:2387418
    See related
    Ensembl:ENSMUSG00000070902 AllianceGenome:MGI:2387418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2czf48
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in early conceptus; oocyte; and secondary oocyte. Orthologous to human KLF18 (Kruppel like factor 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C5; 4 42.31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (90107057..90113924)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (90218820..90225687)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10743 Neighboring gene predicted gene, 54239 Neighboring gene STARR-seq mESC enhancer starr_10744 Neighboring gene STARR-seq mESC enhancer starr_10745 Neighboring gene doublesex and mab-3 related transcription factor like family A1 Neighboring gene STARR-positive B cell enhancer mm9_chr4:89542396-89542697 Neighboring gene STARR-seq mESC enhancer starr_10746 Neighboring gene STARR-seq mESC enhancer starr_10748 Neighboring gene STARR-seq mESC enhancer starr_10749 Neighboring gene STARR-seq mESC enhancer starr_10750 Neighboring gene STARR-seq mESC enhancer starr_10751 Neighboring gene STARR-seq mESC enhancer starr_10752 Neighboring gene STARR-seq mESC enhancer starr_10753 Neighboring gene STARR-seq mESC enhancer starr_10754 Neighboring gene STARR-seq mESC enhancer starr_10755 Neighboring gene STARR-seq mESC enhancer starr_10756 Neighboring gene STARR-seq mESC enhancer starr_10757 Neighboring gene zinc finger protein 352 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network. Li Z, et al. Nat Commun, 2023 Jun 20. PMID 37339952, Free PMC Article
    2. Display of different modes of transcription by the promoters of an early embryonic gene, Zfp352, in preimplantation embryos and in somatic cells. Liu TY, et al. Mol Reprod Dev, 2003 Jan. PMID 12420299
    3. Generation of two homologous and intronless zinc-finger protein genes, zfp352 and zfp353, with different expression patterns by retrotransposition. Chen HH, et al. Genomics, 2002 Jan. PMID 11827453
    4. In silico mining of EST databases for novel pre-implantation embryo-specific zinc finger protein genes. Choo KB, et al. Mol Reprod Dev, 2001 Jul. PMID 11424210
    5. Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells. Choi YJ, et al. Science, 2017 Feb 10. PMID 28082412, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of Zfp352 in the regulation of transient expression of 2-cell specific genes in mouse embryonic stem cells.
      Title: The role of Zfp352 in the regulation of transient expression of 2-cell specific genes in mouse embryonic stem cells.
    2. Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network.
      Title: Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network.
    3. the major Zfp352 promoter, designated P1 and located upstream of exon 1, is utilized in both early embryos and in somatic cells
      Title: Display of different modes of transcription by the promoters of an early embryonic gene, Zfp352, in preimplantation embryos and in somatic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kruppel-like factor 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153102.3 → NP_694742.2  Kruppel-like factor 18

      Status: VALIDATED

      Source sequence(s)
      AL807767
      Consensus CDS
      CCDS18353.2
      UniProtKB/TrEMBL
      A2AML7, Q8VI41
      Related
      ENSMUSP00000102746.2, ENSMUST00000107129.2
      Conserved Domains (1) summary
      sd00017
      Location:464 → 483
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      90107057..90113924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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