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    Lama2 laminin, alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 16773, updated on 8-Jul-2021

    Summary

    Official Symbol
    Lama2provided by MGI
    Official Full Name
    laminin, alpha 2provided by MGI
    Primary source
    MGI:MGI:99912
    See related
    Ensembl:ENSMUSG00000019899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dy; me; mer; merosin; mKIAA4087; 5830440B04
    Expression
    Broad expression in bladder adult (RPKM 7.3), heart adult (RPKM 7.3) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lama2 in Genome Data Viewer
    Location:
    10 A4; 10 14.23 cM
    Exon count:
    66
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (26857281..27493021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (26981285..27617191, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (26701091..27336748, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 18 Neighboring gene predicted gene, 30534 Neighboring gene predicted gene, 40618 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene RIKEN cDNA 4930579H20 gene Neighboring gene predicted gene, 30165 Neighboring gene predicted gene, 30228 Neighboring gene predicted gene, 18041

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4087

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    laminin subunit alpha-2
    Names
    dystrophia muscularis
    laminin M chain
    laminin-12 subunit alpha
    laminin-2 subunit alpha
    laminin-4 subunit alpha
    merosin heavy chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008481.2NP_032507.2  laminin subunit alpha-2 precursor

      See identical proteins and their annotated locations for NP_032507.2

      Status: VALIDATED

      Source sequence(s)
      AC153800, AK030879, AK076479, AK220480, BB637328, BC039991, CD350015
      Consensus CDS
      CCDS48526.1
      UniProtKB/Swiss-Prot
      Q60675
      UniProtKB/TrEMBL
      Q5DTP0
      Related
      ENSMUSP00000090304.6, ENSMUST00000092639.12
      Conserved Domains (12) summary
      smart00180
      Location:9631007
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:12251360
      LamB; Laminin B domain
      cd00055
      Location:913960
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:29373089
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00052
      Location:579707
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:10561104
      Laminin_EGF; Laminin EGF domain
      pfam00054
      Location:27892917
      Laminin_G_1; Laminin G domain
      pfam00055
      Location:45281
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam01442
      Location:18452059
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam06008
      Location:15841848
      Laminin_I; Laminin Domain I
      pfam06009
      Location:20332168
      Laminin_II; Laminin Domain II
      cl02488
      Location:16821881
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      26857281..27493021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313815.1XP_017169304.1  laminin subunit alpha-2 isoform X3

      Conserved Domains (11) summary
      smart00180
      Location:9631007
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:12251360
      LamB; Laminin B domain
      COG1196
      Location:16972010
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00055
      Location:913960
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:29313083
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:15891848
      Laminin_I; Laminin Domain I
      pfam00054
      Location:27832911
      Laminin_G_1; Laminin G domain
      pfam00052
      Location:579718
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:10561104
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:45281
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam06009
      Location:20332166
      Laminin_II; Laminin Domain II
    2. XM_011243134.1XP_011241436.1  laminin subunit alpha-2 isoform X1

      Conserved Domains (11) summary
      smart00180
      Location:9631007
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:12251360
      LamB; Laminin B domain
      COG1196
      Location:16972010
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00055
      Location:913960
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:29353087
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:15891848
      Laminin_I; Laminin Domain I
      pfam00054
      Location:27872915
      Laminin_G_1; Laminin G domain
      pfam00052
      Location:579718
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:10561104
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:45281
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam06009
      Location:20332166
      Laminin_II; Laminin Domain II
    3. XM_011243135.1XP_011241437.1  laminin subunit alpha-2 isoform X2

      Conserved Domains (11) summary
      smart00180
      Location:9631007
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:12251360
      LamB; Laminin B domain
      COG1196
      Location:16972010
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00055
      Location:913960
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:29333085
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:15891848
      Laminin_I; Laminin Domain I
      pfam00054
      Location:27852913
      Laminin_G_1; Laminin G domain
      pfam00052
      Location:579718
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:10561104
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:45281
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam06009
      Location:20332168
      Laminin_II; Laminin Domain II
    4. XM_006512566.5XP_006512629.1  laminin subunit alpha-2 isoform X4

      Conserved Domains (8) summary
      smart00180
      Location:9631007
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:12251360
      LamB; Laminin B domain
      cd00055
      Location:913960
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      TIGR02169
      Location:17581951
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam06008
      Location:15891848
      Laminin_I; Laminin Domain I
      pfam00052
      Location:579718
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:10561104
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:45281
      Laminin_N; Laminin N-terminal (Domain VI)
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