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    Smc4 structural maintenance of chromosomes 4 [ Mus musculus (house mouse) ]

    Gene ID: 70099, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Smc4provided by MGI
    Official Full Name
    structural maintenance of chromosomes 4provided by MGI
    Primary source
    MGI:MGI:1917349
    See related
    Ensembl:ENSMUSG00000034349 AllianceGenome:MGI:1917349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMC-4; Smc4l1; 2500002A22Rik
    Summary
    Enables chromatin binding activity and single-stranded DNA binding activity. Acts upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Located in chromosome, centromeric region. Part of condensin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 30.9), CNS E11.5 (RPKM 28.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 E1; 3 32.14 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (68912071..68941956)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69004738..69034623)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110032F04 gene Neighboring gene STARR-seq mESC enhancer starr_07914 Neighboring gene intraflagellar transport 80 Neighboring gene oxysterol binding protein-like 9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07915 Neighboring gene STARR-seq mESC enhancer starr_07916 Neighboring gene STARR-seq mESC enhancer starr_07917 Neighboring gene STARR-positive B cell enhancer ABC_E3436 Neighboring gene microRNA 16-2 Neighboring gene microRNA 15b Neighboring gene tripartite motif-containing 59 Neighboring gene RIKEN cDNA 9630025H16 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Shaping the metaphase chromosome: coordination of cohesion and condensation. Losada A, et al. Bioessays, 2001 Oct. PMID 11598959
    2. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Strunnikov AV, et al. Eur J Biochem, 1999 Jul. PMID 10429180
    3. Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia. Peng L, et al. Leuk Lymphoma, 2018 Oct. PMID 29043883
    4. Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Griese JJ, et al. Nucleic Acids Res, 2010 Jun. PMID 20139420, Free PMC Article
    5. TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway. Yang Z, et al. FEBS J, 2023 Mar. PMID 36181338

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kinetochore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single strand break repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of condensin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of condensin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    structural maintenance of chromosomes protein 4
    Names
    SMC protein 4
    SMC4 structural maintenance of chromosomes 4-like 1
    XCAP-C homolog
    chromosome-associated polypeptide C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356976.1 → NP_001343905.1  structural maintenance of chromosomes protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122876, BC062939
      UniProtKB/TrEMBL
      E9Q2X6, Q6P7V9
      Conserved Domains (1) summary
      pfam02463
      Location:11 → 1202
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_133786.4 → NP_598547.1  structural maintenance of chromosomes protein 4 isoform 1

      See identical proteins and their annotated locations for NP_598547.1

      Status: VALIDATED

      Source sequence(s)
      AC122876, BC062939, CN722683
      Consensus CDS
      CCDS17401.1
      UniProtKB/Swiss-Prot
      Q8BTS7, Q8BTY9, Q8CG47, Q99K21
      UniProtKB/TrEMBL
      E9Q2X6
      Related
      ENSMUSP00000047872.9, ENSMUST00000042901.15
      Conserved Domains (1) summary
      pfam02463
      Location:81 → 1272
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      68912071..68941956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252813.2 → XP_030108673.1  structural maintenance of chromosomes protein 4 isoform X3

      UniProtKB/TrEMBL
      E9Q2X6
      Conserved Domains (1) summary
      COG1196
      Location:11 → 1042
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006502046.3 → XP_006502109.1  structural maintenance of chromosomes protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006502109.1

      UniProtKB/Swiss-Prot
      Q8BTS7, Q8BTY9, Q8CG47, Q99K21
      UniProtKB/TrEMBL
      E9Q2X6
      Conserved Domains (1) summary
      pfam02463
      Location:81 → 1272
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_030252812.2 → XP_030108672.1  structural maintenance of chromosomes protein 4 isoform X2

      UniProtKB/TrEMBL
      E9Q2X6, Q6P7V9
      Conserved Domains (1) summary
      pfam02463
      Location:11 → 1202
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_036163300.1 → XP_036019193.1  structural maintenance of chromosomes protein 4 isoform X3

      UniProtKB/TrEMBL
      E9Q2X6
      Conserved Domains (1) summary
      COG1196
      Location:11 → 1042
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_036163301.1 → XP_036019194.1  structural maintenance of chromosomes protein 4 isoform X3

      UniProtKB/TrEMBL
      E9Q2X6
      Conserved Domains (1) summary
      COG1196
      Location:11 → 1042
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CG47.1 GenPept UniProtKB/Swiss-Prot:Q8CG47

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