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    Cars1 cysteinyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 27267, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cars1provided by MGI
    Official Full Name
    cysteinyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:1351477
    See related
    Ensembl:ENSMUSG00000010755 AllianceGenome:MGI:1351477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CA3; Cars
    Summary
    Predicted to enable several functions, including ATP binding activity; cysteine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.8), liver E14 (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F5; 7 88.25 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143110967..143153827, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143557230..143600090, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene predicted gene, 23297 Neighboring gene STARR-positive B cell enhancer ABC_E1362 Neighboring gene microRNA 7064 Neighboring gene STARR-seq mESC enhancer starr_20532 Neighboring gene STARR-seq mESC enhancer starr_20533 Neighboring gene STARR-positive B cell enhancer ABC_E1098 Neighboring gene predicted gene 15580 Neighboring gene predicted gene 15579 Neighboring gene tumor necrosis factor receptor superfamily, member 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genes induced by growth arrest in a pancreatic beta cell line: identification by analysis of cDNA arrays. Zimmer Y, et al. FEBS Lett, 1999 Aug 20. PMID 10486565
    2. Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene. Sowden J, et al. Gene, 1998 Jul 3. PMID 9651514
    3. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Schneider P, et al. J Biol Chem, 2003 Feb 14. PMID 12466268
    4. Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. Yatsuki H, et al. DNA Res, 2000 Jun 30. PMID 10907850
    5. Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Mohammad F, et al. Development, 2010 Aug 1. PMID 20573698

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cysteine--tRNA ligase, cytoplasmic
    Names
    cysRS
    cysteinyl-tRNA synthetase, cytoplasmic
    NP_001239522.1
    NP_038770.3
    XP_006508690.1
    XP_011240303.1
    XP_017177784.1
    XP_030098491.1
    XP_036009038.1
    XP_036009039.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252593.1 → NP_001239522.1  cysteine--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001239522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK152866, BC030473, BY021374, BY253195
      Consensus CDS
      CCDS57597.1
      UniProtKB/TrEMBL
      Q3U716, Q3UXN3
      Related
      ENSMUSP00000101529.4, ENSMUST00000105909.4
      Conserved Domains (2) summary
      cd00672
      Location:30 → 445
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      PTZ00399
      Location:1 → 739
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    2. NM_013742.5 → NP_038770.3  cysteine--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_038770.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AJ276796, AK135433, BC030473, BY021374, BY253195
      Consensus CDS
      CCDS40198.1
      UniProtKB/Swiss-Prot
      O88303, Q8BP81, Q8CAY7, Q8CCE3, Q8K0S4, Q9ER68, Q9ER72
      UniProtKB/TrEMBL
      Q3UXN3
      Related
      ENSMUSP00000010899.8, ENSMUST00000010899.14
      Conserved Domains (3) summary
      cd00672
      Location:113 → 528
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      cd10310
      Location:4 → 76
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91 → 827
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143110967..143153827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153145.1 → XP_036009038.1  cysteine--tRNA ligase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      Q3UXN3
      Conserved Domains (2) summary
      cd10310
      Location:4 → 76
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91 → 720
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    2. XM_011242001.2 → XP_011240303.1  cysteine--tRNA ligase, cytoplasmic isoform X4

      See identical proteins and their annotated locations for XP_011240303.1

      Conserved Domains (1) summary
      PTZ00399
      Location:118 → 647
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    3. XM_006508627.3 → XP_006508690.1  cysteine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      Q3UXN3
      Conserved Domains (2) summary
      cd10310
      Location:4 → 76
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91 → 807
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    4. XM_030242631.1 → XP_030098491.1  cysteine--tRNA ligase, cytoplasmic isoform X4

      Conserved Domains (1) summary
      PTZ00399
      Location:118 → 647
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    5. XM_036153146.1 → XP_036009039.1  cysteine--tRNA ligase, cytoplasmic isoform X5

      Conserved Domains (1) summary
      PTZ00399
      Location:45 → 522
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    6. XM_017322295.1 → XP_017177784.1  cysteine--tRNA ligase, cytoplasmic isoform X3

      UniProtKB/TrEMBL
      Q3UXN3
      Conserved Domains (2) summary
      cd10310
      Location:4 → 76
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91 → 690
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    RNA

    1. XR_378611.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER72.2 GenPept UniProtKB/Swiss-Prot:Q9ER72

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