Nlrp6 NLR family, pyrin domain containing 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrp6provided by MGI
Official Full Name: NLR family, pyrin domain containing 6provided by MGI
Primary source: MGI:MGI:2141990
See related: Ensembl:ENSMUSG00000038745 AllianceGenome:MGI:2141990
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Avr; Navr; Nalp6; Pypaf5; Non-AVR; Navr/Avr
Summary: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]
Expression: Biased expression in large intestine adult (RPKM 52.0), liver adult (RPKM 39.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.14 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140500777..140509105)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (140920902..140929192)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1.
Title: NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1.
NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner.
Title: NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner.
NPAS4 Exacerbates Pyroptosis via Transcriptionally Regulating NLRP6 in the Acute Phase of Intracerebral Hemorrhage in Mice.
Title: NPAS4 Exacerbates Pyroptosis via Transcriptionally Regulating NLRP6 in the Acute Phase of Intracerebral Hemorrhage in Mice.
NLRP6 deficiency expands a novel CD103[+] B cell population that confers immune tolerance in NOD mice.
Title: NLRP6 deficiency expands a novel CD103(+) B cell population that confers immune tolerance in NOD mice.
NLRP6 negatively regulates type 2 immune responses in mice.
Title: NLRP6 negatively regulates type 2 immune responses in mice.
NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer.
Title: NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer.
The important role of NLRP6 inflammasome in Pasteurella multocida infection.
Title: The important role of NLRP6 inflammasome in Pasteurella multocida infection.
Estrogen receptor beta activation inhibits colitis by promoting NLRP6-mediated autophagy.
Title: Estrogen receptor β activation inhibits colitis by promoting NLRP6-mediated autophagy.
Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury.
Title: Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury.
NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease.
Title: NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

RH126401 (e-PCR)
- UniSTS:163109

D7Mit257 (e-PCR), detects polymorphism
- UniSTS:131153

AI504961 (e-PCR)
- UniSTS:159712

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipoteichoic acid binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NLRP6 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in NLRP6 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acute inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within acute inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in antiviral innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
NOT involved_in host-mediated regulation of intestinal microbiota composition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in host-mediated regulation of intestinal microbiota composition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-18 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil-mediated killing of gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-18-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-18-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in pyroptosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pyroptosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NLRP6 inflammasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of NLRP6 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of canonical inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of canonical inflammasome complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in non-membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in non-membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 6

Names: NACHT, leucine rich repeat and PYD containing 6; NACHT/LRR/pyrin domain-containing protein 6; PYRIN-containing APAF1-like protein 5; angiotensin II/vasopressin receptor; non-angiotensin-vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133946.3 → NP_598707.2 NACHT, LRR and PYD domains-containing protein 6

See identical proteins and their annotated locations for NP_598707.2

Status: VALIDATED

Source sequence(s)

AC107815, AC162287

Consensus CDS

CCDS40178.2

UniProtKB/Swiss-Prot

C9W978, F8UKQ6, Q67EY0, Q8K0L4, Q91WS2

UniProtKB/TrEMBL

E9QNS0

Related

ENSMUSP00000139357.2, ENSMUST00000183845.8

Conserved Domains (3) summary

cd00116
Location:617 → 863

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08321
Location:16 → 96

Pyrin_ASC-like; Pyrin Death Domain found in ASC

pfam05729
Location:195 → 348

NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

140500777..140509105

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081389.1: Suppressed sequence

Description

NM_001081389.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.