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    Helz helicase with zinc finger domain [ Mus musculus (house mouse) ]

    Gene ID: 78455, updated on 22-May-2024

    Summary

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    Official Symbol
    Helzprovided by MGI
    Official Full Name
    helicase with zinc finger domainprovided by MGI
    Primary source
    MGI:MGI:1925705
    See related
    Ensembl:ENSMUSG00000020721 AllianceGenome:MGI:1925705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DRHC; 3110078M01Rik; 9430093I07Rik; 9630002H22Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in post-transcriptional gene silencing by RNA. Predicted to be located in nucleus. Predicted to be active in P granule and cytosol. Is expressed in retina outer nuclear layer. Orthologous to human HELZ (helicase with zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.0), placenta adult (RPKM 5.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Helz in Genome Data Viewer
    Location:
    11 E1; 11 70.29 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (107437789..107584652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (107546963..107693826)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:107340564-107340865 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Neighboring gene STARR-seq mESC enhancer starr_30988 Neighboring gene RIKEN cDNA A830035A12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107390700-107390809 Neighboring gene STARR-seq mESC enhancer starr_30991 Neighboring gene predicted gene, 39426 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107434682-107434883 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107436638-107436803 Neighboring gene STARR-seq mESC enhancer starr_30994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107505802-107506005 Neighboring gene microRNA 6932 Neighboring gene calcium channel, voltage-dependent, gamma subunit 1 Neighboring gene calcium channel, voltage-dependent, gamma subunit 4 Neighboring gene VISTA enhancer mm1348 Neighboring gene predicted gene 11650

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart. Bian Y, et al. J Mol Cell Cardiol, 2021 Sep. PMID 34043986
    2. Identification of a differentially expressed RNA helicase by gene trapping. Wagner DS, et al. Biochem Biophys Res Commun, 1999 Sep 7. PMID 10471385
    3. The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation. Hasgall PA, et al. PLoS One, 2011. PMID 21765940, Free PMC Article
    4. Cardiac deletion of Smyd2 is dispensable for mouse heart development. Diehl F, et al. PLoS One, 2010 Mar 17. PMID 20305823, Free PMC Article
    5. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart.
      Title: CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart.
    2. Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6.
      Title: The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.
    3. Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ
      Title: Cardiac deletion of Smyd2 is dispensable for mouse heart development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0054

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable helicase with zinc finger domain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368755.1 → NP_001355684.1  probable helicase with zinc finger domain isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645947
      Consensus CDS
      CCDS88275.1
      UniProtKB/Swiss-Prot
      A1L4L4, A2AAU4, Q6DFV5, Q8BZZ6, Q8CHI3, Q8VDI3
      Related
      ENSMUSP00000102357.2, ENSMUST00000106746.8
      Conserved Domains (5) summary
      smart00818
      Location:1337 → 1413
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:868 → 1068
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641 → 867
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181 → 204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:1261 → 1415
      Atrophin-1; Atrophin-1 family

    2. NM_198298.2 → NP_938040.1  probable helicase with zinc finger domain isoform 1

      See identical proteins and their annotated locations for NP_938040.1

      Status: VALIDATED

      Source sequence(s)
      AL645947
      Consensus CDS
      CCDS25569.1
      UniProtKB/Swiss-Prot
      Q6DFV5
      UniProtKB/TrEMBL
      A0A0R4J0Y3
      Related
      ENSMUSP00000074533.2, ENSMUST00000075012.8
      Conserved Domains (5) summary
      smart00818
      Location:1338 → 1414
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:869 → 1069
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641 → 868
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181 → 204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:1262 → 1416
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      107437789..107584652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534505.5 → XP_006534568.1  probable helicase with zinc finger domain isoform X1

      See identical proteins and their annotated locations for XP_006534568.1

      UniProtKB/Swiss-Prot
      Q6DFV5
      UniProtKB/TrEMBL
      A0A0R4J0Y3
      Conserved Domains (5) summary
      smart00818
      Location:1338 → 1414
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:869 → 1069
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641 → 868
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181 → 204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:1262 → 1416
      Atrophin-1; Atrophin-1 family

    2. XM_006534506.5 → XP_006534569.1  probable helicase with zinc finger domain isoform X1

      See identical proteins and their annotated locations for XP_006534569.1

      UniProtKB/Swiss-Prot
      Q6DFV5
      UniProtKB/TrEMBL
      A0A0R4J0Y3
      Conserved Domains (5) summary
      smart00818
      Location:1338 → 1414
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:869 → 1069
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641 → 868
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181 → 204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:1262 → 1416
      Atrophin-1; Atrophin-1 family

    3. XM_006534504.1 → XP_006534567.1  probable helicase with zinc finger domain isoform X1

      See identical proteins and their annotated locations for XP_006534567.1

      UniProtKB/Swiss-Prot
      Q6DFV5
      UniProtKB/TrEMBL
      A0A0R4J0Y3
      Conserved Domains (5) summary
      smart00818
      Location:1338 → 1414
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:869 → 1069
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641 → 868
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181 → 204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:1262 → 1416
      Atrophin-1; Atrophin-1 family

    4. XM_036157092.1 → XP_036012985.1  probable helicase with zinc finger domain isoform X3

      Conserved Domains (4) summary
      cd18808
      Location:834 → 1034
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      pfam00642
      Location:181 → 205
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:1143 → 1374
      Atrophin-1; Atrophin-1 family
      cl28899
      Location:641 → 833
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    5. XM_030246430.1 → XP_030102290.1  probable helicase with zinc finger domain isoform X2

      UniProtKB/Swiss-Prot
      A1L4L4, A2AAU4, Q6DFV5, Q8BZZ6, Q8CHI3, Q8VDI3
      Related
      ENSMUSP00000097878.2, ENSMUST00000100305.8
      Conserved Domains (5) summary
      smart00818
      Location:1337 → 1413
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:868 → 1068
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641 → 867
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181 → 204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:1261 → 1415
      Atrophin-1; Atrophin-1 family

    6. XM_036157093.1 → XP_036012986.1  probable helicase with zinc finger domain isoform X3

      Conserved Domains (4) summary
      cd18808
      Location:834 → 1034
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      pfam00642
      Location:181 → 205
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:1143 → 1374
      Atrophin-1; Atrophin-1 family
      cl28899
      Location:641 → 833
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DFV5.2 GenPept UniProtKB/Swiss-Prot:Q6DFV5

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