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    Ten1 TEN1 telomerase capping complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 69535, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ten1provided by MGI
    Official Full Name
    TEN1 telomerase capping complex subunitprovided by MGI
    Primary source
    MGI:MGI:1916785
    See related
    Ensembl:ENSMUSG00000020778 AllianceGenome:MGI:1916785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310004N24Rik
    Summary
    Predicted to enable telomerase inhibitor activity and telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase. Located in chromosome, telomeric region and nucleus. Part of CST complex. Orthologous to human TEN1 (TEN1 subunit of CST complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 25.4), colon adult (RPKM 24.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 81.0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116089681..116106144)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116198855..116215318)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Fas binding factor 1 Neighboring gene predicted gene, 26413 Neighboring gene acyl-Coenzyme A oxidase 1, palmitoyl Neighboring gene STARR-seq mESC enhancer starr_31195 Neighboring gene cyclin dependent kinase 3 Neighboring gene envoplakin Neighboring gene predicted gene, 33250

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Miyake Y, et al. Mol Cell, 2009 Oct 23. PMID 19854130
    2. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CST complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CST complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CST complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CST complex subunit TEN1
    Names
    protein telomeric pathways with STN1 homolog
    telomere length regulation protein TEN1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027107.1 → NP_081383.1  CST complex subunit TEN1

      See identical proteins and their annotated locations for NP_081383.1

      Status: VALIDATED

      Source sequence(s)
      AK009156, AL669925, BQ030877
      Consensus CDS
      CCDS48982.1
      UniProtKB/Swiss-Prot
      Q9D7K2
      Related
      ENSMUSP00000021130.7, ENSMUST00000021130.7
      Conserved Domains (1) summary
      pfam15490
      Location:2 → 118
      Ten1_2; Telomere-capping, CST complex subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116089681..116106144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7K2.1 GenPept UniProtKB/Swiss-Prot:Q9D7K2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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