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    Cars2 cysteinyl-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 71941, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cars2provided by MGI
    Official Full Name
    cysteinyl-tRNA synthetase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1919191
    See related
    Ensembl:ENSMUSG00000056228 AllianceGenome:MGI:1919191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cysRS; 2310051N18Rik; 2410044A07Rik; D530030H10Rik
    Summary
    Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in metanephros. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 22.7), ovary adult (RPKM 18.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11564017..11600781, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11514017..11550781, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RAB20, member RAS oncogene family Neighboring gene RIKEN cDNA E230013L22 gene Neighboring gene NAD(P)HX dehydratase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:11550723-11550832 Neighboring gene STARR-seq mESC enhancer starr_20716 Neighboring gene STARR-positive B cell enhancer ABC_E9718 Neighboring gene STARR-positive B cell enhancer ABC_E2856 Neighboring gene STARR-positive B cell enhancer ABC_E1101 Neighboring gene inhibitor of growth family, member 1 Neighboring gene ankyrin repeat domain 10 Neighboring gene STARR-seq mESC enhancer starr_20718 Neighboring gene STARR-positive B cell enhancer ABC_E9307 Neighboring gene microRNA 7238

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Akaike T, et al. Nat Commun, 2017 Oct 27. PMID 29079736, Free PMC Article
    2. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable cysteine--tRNA ligase, mitochondrial
    Names
    cysteine--tRNA ligase
    cysteinyl-tRNA synthetase 2 (mitochondrial)(putative)
    probable cysteinyl-tRNA synthetase, mitochondrial
    NP_001346066.1
    NP_077210.1
    XP_006508953.1
    XP_011240384.1
    XP_030099634.1
    XP_030099635.1
    XP_030099636.1
    XP_030099637.1
    XP_030099638.1
    XP_030099639.1
    XP_030099640.1
    XP_030099641.1
    XP_036010192.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359137.1 → NP_001346066.1  probable cysteine--tRNA ligase, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK038968, BF458069
      UniProtKB/Swiss-Prot
      Q8BYM8, Q9D6U9
      Conserved Domains (1) summary
      cl27478
      Location:27 → 546
      tRNA-synt_1e; tRNA synthetases class I (C) catalytic domain

    2. NM_024248.1 → NP_077210.1  probable cysteine--tRNA ligase, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_077210.1

      Status: VALIDATED

      Source sequence(s)
      AK009937, AK038968, BF458069, CX204497
      Consensus CDS
      CCDS52478.1
      UniProtKB/TrEMBL
      G3X975
      Related
      ENSMUSP00000046453.6, ENSMUST00000049461.7
      Conserved Domains (3) summary
      cd00672
      Location:38 → 342
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      COG0215
      Location:38 → 539
      CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl12020
      Location:391 → 427
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      11564017..11600781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243775.1 → XP_030099635.1  probable cysteine--tRNA ligase, mitochondrial isoform X4

      Conserved Domains (1) summary
      PTZ00399
      Location:69 → 554
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    2. XM_030243774.1 → XP_030099634.1  probable cysteine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PTZ00399
      Location:69 → 555
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    3. XM_006508890.3 → XP_006508953.1  probable cysteine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      PTZ00399
      Location:27 → 613
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    4. XM_011242082.2 → XP_011240384.1  probable cysteine--tRNA ligase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PTZ00399
      Location:27 → 614
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    5. XM_030243779.2 → XP_030099639.1  probable cysteine--tRNA ligase, mitochondrial isoform X7

      Conserved Domains (1) summary
      PTZ00399
      Location:8 → 430
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    6. XM_036154299.1 → XP_036010192.1  probable cysteine--tRNA ligase, mitochondrial isoform X7

      Conserved Domains (1) summary
      PTZ00399
      Location:8 → 430
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    7. XM_030243777.1 → XP_030099637.1  probable cysteine--tRNA ligase, mitochondrial isoform X6

      Conserved Domains (1) summary
      PTZ00399
      Location:8 → 497
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    8. XM_030243776.1 → XP_030099636.1  probable cysteine--tRNA ligase, mitochondrial isoform X5

      Conserved Domains (1) summary
      PTZ00399
      Location:8 → 498
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    9. XM_030243781.1 → XP_030099641.1  probable cysteine--tRNA ligase, mitochondrial isoform X9

      Conserved Domains (1) summary
      COG0215
      Location:79 → 303
      CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    10. XM_030243778.1 → XP_030099638.1  probable cysteine--tRNA ligase, mitochondrial isoform X8

      Conserved Domains (1) summary
      PTZ00399
      Location:8 → 431
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    11. XM_030243780.1 → XP_030099640.1  probable cysteine--tRNA ligase, mitochondrial isoform X9

      Conserved Domains (1) summary
      COG0215
      Location:79 → 303
      CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_004934882.1 RNA Sequence

      Related
      ENSMUST00000210478.2

    2. XR_004934881.1 RNA Sequence

    3. XR_004934880.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYM8.2 GenPept UniProtKB/Swiss-Prot:Q8BYM8

    Gene LinkOut

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