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    Nr2c2ap nuclear receptor 2C2-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 75692, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nr2c2approvided by MGI
    Official Full Name
    nuclear receptor 2C2-associated proteinprovided by MGI
    Primary source
    MGI:MGI:1922942
    See related
    Ensembl:ENSMUSG00000071078 AllianceGenome:MGI:1922942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310073E15Rik
    Summary
    Predicted to be located in nucleoplasm. Orthologous to human NR2C2AP (nuclear receptor 2C2 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 15.0), thymus adult (RPKM 13.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70583977..70586402)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70131327..70133752)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene neurocan Neighboring gene microRNA 7066 Neighboring gene predicted gene, 25906 Neighboring gene regulatory factor X-associated ankyrin-containing protein Neighboring gene STARR-positive B cell enhancer ABC_E1102 Neighboring gene BLOC-1 related complex subunit 8 Neighboring gene myocyte enhancer factor 2B like Neighboring gene STARR-seq mESC enhancer starr_21765 Neighboring gene STARR-positive B cell enhancer ABC_E3776 Neighboring gene myocyte enhancer factor 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103332

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor 2C2-associated protein
    Names
    TR4 orphan receptor-associated 16 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025586.2 → NP_001020757.1  nuclear receptor 2C2-associated protein isoform 1

      See identical proteins and their annotated locations for NP_001020757.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AA111465, AK160346, BY100716
      Consensus CDS
      CCDS40366.1
      UniProtKB/Swiss-Prot
      Q3TV70
      Related
      ENSMUSP00000092907.6, ENSMUST00000095273.7
      Conserved Domains (1) summary
      cl02148
      Location:12 → 91
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    2. NM_001025587.2 → NP_001020758.1  nuclear receptor 2C2-associated protein isoform 2

      See identical proteins and their annotated locations for NP_001020758.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This encodes a protein (isoform 2) that is shorter than isoform 1.
      Source sequence(s)
      AA111465, AK010864, AK160346, BY100716
      UniProtKB/TrEMBL
      Q569V8
      Conserved Domains (1) summary
      cl02148
      Location:12 → 102
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    RNA

    1. NR_104434.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AA111465, AK010864, BY100716
      Related
      ENSMUST00000211898.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70583977..70586402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509777.2 → XP_006509840.1  nuclear receptor 2C2-associated protein isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025588.1: Suppressed sequence

      Description
      NM_001025588.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TV70.1 GenPept UniProtKB/Swiss-Prot:Q3TV70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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    Tools
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