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    Rreb1 ras responsive element binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 68750, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rreb1provided by MGI
    Official Full Name
    ras responsive element binding protein 1provided by MGI
    Primary source
    MGI:MGI:2443664
    See related
    Ensembl:ENSMUSG00000039087 AllianceGenome:MGI:2443664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sao; 1110037N09Rik; B930013M22Rik
    Summary
    Enables DNA-binding transcription factor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of brown fat cell differentiation. Acts upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in fibrillar center and nuclear speck. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and pancreas epithelium. Orthologous to human RREB1 (ras responsive element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 5.6), colon adult (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A3.3; 13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (37962362..38135981)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (37778382..37952005)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34225 Neighboring gene predicted gene, 40918 Neighboring gene STARR-seq mESC enhancer starr_34227 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37870871-37870980 Neighboring gene predicted gene, 31600 Neighboring gene STARR-positive B cell enhancer mm9_chr13:37884809-37885110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37893604-37893840 Neighboring gene predicted gene, 46411 Neighboring gene STARR-positive B cell enhancer ABC_E1461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37972487-37972670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37974410-37974611 Neighboring gene STARR-seq mESC enhancer starr_34234 Neighboring gene STARR-positive B cell enhancer ABC_E11541 Neighboring gene STARR-positive B cell enhancer ABC_E7227 Neighboring gene STARR-positive B cell enhancer ABC_E10789 Neighboring gene predicted gene, 52041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38086110-38086293 Neighboring gene signal sequence receptor, alpha Neighboring gene STARR-positive B cell enhancer ABC_E9396 Neighboring gene cancer antigen 1 Neighboring gene RIO kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis. Inubushi T, et al. Dis Model Mech, 2022 Feb 1. PMID 34897389, Free PMC Article
    2. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes. Kent OA, et al. Nat Commun, 2020 Sep 16. PMID 32938917, Free PMC Article
    3. TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1. Su J, et al. Nature, 2020 Jan. PMID 31915377, Free PMC Article
    4. Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice. Yamane T, et al. PLoS One, 2013. PMID 24348900, Free PMC Article
    5. Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1. Chen RL, et al. J Biol Chem, 2010 Apr 2. PMID 20133935, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RREB1 regulates neuronal proteostasis and the microtubule network.
      Title: RREB1 regulates neuronal proteostasis and the microtubule network.
    2. Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis.
      Title: Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis.
    3. The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.
      Title: The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.
    4. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes.
      Title: Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes.
    5. identification of RAS-responsive element binding protein 1 (RREB1), a RAS transcriptional effector, as a key partner of TGF-beta-activated SMAD transcription factors in epithelial-to-mesenchymal transitions
      Title: TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (2) 
    • Endonuclease-mediated (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-responsive element-binding protein 1
    Names
    RAS-responsive zinc finger transcription factor RREB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039188.2 → NP_001034277.1  ras-responsive element-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001034277.1

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477
      Consensus CDS
      CCDS36634.1
      UniProtKB/Swiss-Prot
      Q3UH06
      Related
      ENSMUSP00000105866.3, ENSMUST00000110237.9
      Conserved Domains (3) summary
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:111 → 136
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001177868.2 → NP_001171339.1  ras-responsive element-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001171339.1

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477
      Consensus CDS
      CCDS36634.1
      UniProtKB/Swiss-Prot
      Q3UH06
      Related
      ENSMUSP00000121211.2, ENSMUST00000149745.8
      Conserved Domains (3) summary
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:111 → 136
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001177869.2 → NP_001171340.1  ras-responsive element-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001171340.1

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477
      Consensus CDS
      CCDS49238.1
      UniProtKB/Swiss-Prot
      Q3UH06
      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1602 → 1624
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1588 → 1612
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1575 → 1596
      zf-C2H2_6; C2H2-type zinc finger

    4. NM_001404757.1 → NP_001391686.1  ras-responsive element-binding protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477
      UniProtKB/Swiss-Prot
      B8JJE2, B8JJE3, Q3TB97, Q3UH06, Q4ZE88, Q66JZ8

    5. NM_001404758.1 → NP_001391687.1  ras-responsive element-binding protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477
      UniProtKB/Swiss-Prot
      B8JJE2, B8JJE3, Q3TB97, Q3UH06, Q4ZE88, Q66JZ8

    6. NM_001404759.1 → NP_001391688.1  ras-responsive element-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477

    7. NM_001404760.1 → NP_001391689.1  ras-responsive element-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477

    8. NM_026830.3 → NP_081106.1  ras-responsive element-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_081106.1

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477
      Consensus CDS
      CCDS36634.1
      UniProtKB/Swiss-Prot
      Q3UH06
      Related
      ENSMUSP00000105867.3, ENSMUST00000110238.10
      Conserved Domains (3) summary
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:111 → 136
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_033218.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT010477
      Related
      ENSMUST00000124268.8

    2. NR_033615.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022682, CT010477

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      37962362..38135981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516757.5 → XP_006516820.1  ras-responsive element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006516820.1

      UniProtKB/Swiss-Prot
      Q3UH06
      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1602 → 1624
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1588 → 1612
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1575 → 1596
      zf-C2H2_6; C2H2-type zinc finger

    2. XM_030247397.2 → XP_030103257.1  ras-responsive element-binding protein 1 isoform X4

      Conserved Domains (8) summary
      smart00355
      Location:1171 → 1191
      ZnF_C2H2; zinc finger
      sd00017
      Location:17 → 37
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1520 → 1542
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:299 → 590
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1506 → 1530
      zf-H2C2_2; Zinc-finger double domain
      pfam13894
      Location:124 → 146
      zf-C2H2_4; C2H2-type zinc finger
      pfam13909
      Location:587 → 611
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1493 → 1514
      zf-C2H2_6; C2H2-type zinc finger

    3. XM_006516754.5 → XP_006516817.1  ras-responsive element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006516817.1

      UniProtKB/Swiss-Prot
      Q3UH06
      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1602 → 1624
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1588 → 1612
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1575 → 1596
      zf-C2H2_6; C2H2-type zinc finger

    4. XM_030247395.2 → XP_030103255.1  ras-responsive element-binding protein 1 isoform X4

      Conserved Domains (8) summary
      smart00355
      Location:1171 → 1191
      ZnF_C2H2; zinc finger
      sd00017
      Location:17 → 37
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1520 → 1542
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:299 → 590
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1506 → 1530
      zf-H2C2_2; Zinc-finger double domain
      pfam13894
      Location:124 → 146
      zf-C2H2_4; C2H2-type zinc finger
      pfam13909
      Location:587 → 611
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1493 → 1514
      zf-C2H2_6; C2H2-type zinc finger

    5. XM_030247396.2 → XP_030103256.1  ras-responsive element-binding protein 1 isoform X4

      Conserved Domains (8) summary
      smart00355
      Location:1171 → 1191
      ZnF_C2H2; zinc finger
      sd00017
      Location:17 → 37
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1520 → 1542
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:299 → 590
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1506 → 1530
      zf-H2C2_2; Zinc-finger double domain
      pfam13894
      Location:124 → 146
      zf-C2H2_4; C2H2-type zinc finger
      pfam13909
      Location:587 → 611
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1493 → 1514
      zf-C2H2_6; C2H2-type zinc finger

    6. XM_006516749.3 → XP_006516812.1  ras-responsive element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006516812.1

      UniProtKB/Swiss-Prot
      Q3UH06
      Related
      ENSMUSP00000115599.2, ENSMUST00000128570.9
      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1602 → 1624
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1588 → 1612
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1575 → 1596
      zf-C2H2_6; C2H2-type zinc finger

    7. XM_006516758.3 → XP_006516821.1  ras-responsive element-binding protein 1 isoform X2

      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1551 → 1571
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1549 → 1571
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1265 → 1290
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain

    8. XM_011244341.4 → XP_011242643.1  ras-responsive element-binding protein 1 isoform X4

      Conserved Domains (8) summary
      smart00355
      Location:1171 → 1191
      ZnF_C2H2; zinc finger
      sd00017
      Location:17 → 37
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1520 → 1542
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:299 → 590
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1506 → 1530
      zf-H2C2_2; Zinc-finger double domain
      pfam13894
      Location:124 → 146
      zf-C2H2_4; C2H2-type zinc finger
      pfam13909
      Location:587 → 611
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1493 → 1514
      zf-C2H2_6; C2H2-type zinc finger

    9. XM_006516756.4 → XP_006516819.1  ras-responsive element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006516819.1

      UniProtKB/Swiss-Prot
      Q3UH06
      Related
      ENSMUSP00000049265.8, ENSMUST00000037232.8
      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1602 → 1624
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1588 → 1612
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1575 → 1596
      zf-C2H2_6; C2H2-type zinc finger

    10. XM_006516751.4 → XP_006516814.1  ras-responsive element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006516814.1

      UniProtKB/Swiss-Prot
      Q3UH06
      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1602 → 1624
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1588 → 1612
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1575 → 1596
      zf-C2H2_6; C2H2-type zinc finger

    11. XM_006516752.3 → XP_006516815.1  ras-responsive element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006516815.1

      UniProtKB/Swiss-Prot
      Q3UH06
      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1602 → 1624
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1588 → 1612
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1575 → 1596
      zf-C2H2_6; C2H2-type zinc finger

    12. XM_006516753.5 → XP_006516816.1  ras-responsive element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006516816.1

      UniProtKB/Swiss-Prot
      Q3UH06
      Conserved Domains (8) summary
      smart00355
      Location:1253 → 1273
      ZnF_C2H2; zinc finger
      COG5048
      Location:64 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1602 → 1624
      zf-C2H2; Zinc finger, C2H2 type
      pfam04625
      Location:381 → 672
      DEC-1_N; DEC-1 protein, N-terminal region
      pfam13465
      Location:1588 → 1612
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:669 → 693
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13912
      Location:1575 → 1596
      zf-C2H2_6; C2H2-type zinc finger

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013392.3: Suppressed sequence

      Description
      NM_001013392.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UH06.2 GenPept UniProtKB/Swiss-Prot:Q3UH06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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