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    Tatdn3 TatD DNase domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 68972, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tatdn3provided by MGI
    Official Full Name
    TatD DNase domain containing 3provided by MGI
    Primary source
    MGI:MGI:1916222
    See related
    Ensembl:ENSMUSG00000026632 AllianceGenome:MGI:1916222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500010M24Rik
    Summary
    Predicted to enable metal ion binding activity and nuclease activity. Located in mitochondrion. Orthologous to human TATDN3 (TatD DNase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 7.7), cortex adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H6; 1 96.28 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190778023..190795373, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191045826..191063075, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene feline leukemia virus subgroup C cellular receptor 1 Neighboring gene RIKEN cDNA A230020J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E223 Neighboring gene spermatogenesis associated 45 Neighboring gene STARR-positive B cell enhancer ABC_E4404 Neighboring gene NSL1, MIS12 kinetochore complex component Neighboring gene basic leucine zipper transcription factor, ATF-like 3 Neighboring gene predicted gene, 46178

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative deoxyribonuclease TATDN3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163421.1 → NP_001156893.1  putative deoxyribonuclease TATDN3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC138229
      Consensus CDS
      CCDS48486.1
      UniProtKB/TrEMBL
      D3Z0V5
      Related
      ENSMUSP00000106516.2, ENSMUST00000110891.8
      Conserved Domains (1) summary
      cd01310
      Location:5 → 223
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    2. NM_001163422.1 → NP_001156894.1  putative deoxyribonuclease TATDN3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC138229
      Consensus CDS
      CCDS48484.1
      UniProtKB/Swiss-Prot
      Q3U1C6
      Related
      ENSMUSP00000082773.6, ENSMUST00000085633.12
      Conserved Domains (1) summary
      cl00281
      Location:5 → 158
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    3. NM_001357166.1 → NP_001344095.1  putative deoxyribonuclease TATDN3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138229
      Consensus CDS
      CCDS87944.1
      UniProtKB/Swiss-Prot
      Q3U1C6, Q6P8H6, Q9DB58
      UniProtKB/TrEMBL
      D3YXH9
      Related
      ENSMUSP00000027945.6, ENSMUST00000027945.6
      Conserved Domains (1) summary
      cd01310
      Location:5 → 261
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    4. NM_026895.1 → NP_081171.1  putative deoxyribonuclease TATDN3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC138229
      Consensus CDS
      CCDS48485.1
      UniProtKB/Swiss-Prot
      Q3U1C6, Q6P8H6, Q9DB58
      UniProtKB/TrEMBL
      E9QL22
      Related
      ENSMUSP00000106518.4, ENSMUST00000110893.10
      Conserved Domains (2) summary
      COG1099
      Location:6 → 262
      COG1099; Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only]
      cd01310
      Location:5 → 262
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      190778023..190795373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497204.5 → XP_006497267.1  putative deoxyribonuclease TATDN3 isoform X1

      Conserved Domains (1) summary
      cl00281
      Location:51 → 209
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U1C6.1 GenPept UniProtKB/Swiss-Prot:Q3U1C6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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