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    Tedc2 tubulin epsilon and delta complex 2 [ Mus musculus (house mouse) ]

    Gene ID: 72016, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tedc2provided by MGI
    Official Full Name
    tubulin epsilon and delta complex 2provided by MGI
    Primary source
    MGI:MGI:1919266
    See related
    Ensembl:ENSMUSG00000024118 AllianceGenome:MGI:1919266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1600002H07Rik
    Summary
    Involved in positive regulation of smoothened signaling pathway. Located in centriole and cilium. Orthologous to human TEDC2 (tubulin epsilon and delta complex 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 18.6), liver E14.5 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 12.32 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24434028..24439825, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24215054..24220934, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene netrin 3 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene cyclin F Neighboring gene microRNA 5134 Neighboring gene microRNA 6965

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury. Lee B, et al. J Biol Chem, 2022 Mar. PMID 35101451, Free PMC Article
    2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin epsilon and delta complex protein 2
    Names
    uncharacterized protein C16orf59 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028056.2 → NP_082332.1  tubulin epsilon and delta complex protein 2

      See identical proteins and their annotated locations for NP_082332.1

      Status: VALIDATED

      Source sequence(s)
      AK005395, BC072612
      Consensus CDS
      CCDS28479.1
      UniProtKB/Swiss-Prot
      Q6GQV0, Q9DAZ6
      Related
      ENSMUSP00000024930.8, ENSMUST00000024930.8
      Conserved Domains (1) summary
      pfam15764
      Location:150 → 434
      DUF4693; Domain of unknown function (DUF4693)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24434028..24439825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246632.4 → XP_011244934.1  tubulin epsilon and delta complex protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15764
      Location:150 → 389
      DUF4693; Domain of unknown function (DUF4693)

    2. XM_030250058.2 → XP_030105918.1  tubulin epsilon and delta complex protein 2 isoform X2

      Conserved Domains (1) summary
      pfam15764
      Location:1 → 249
      DUF4693; Domain of unknown function (DUF4693)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GQV0.1 GenPept UniProtKB/Swiss-Prot:Q6GQV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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