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    Rbbp5 retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 213464, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rbbp5provided by MGI
    Official Full Name
    retinoblastoma binding protein 5, histone lysine methyltransferase complex subunitprovided by MGI
    Primary source
    MGI:MGI:1918367
    See related
    Ensembl:ENSMUSG00000026439 AllianceGenome:MGI:1918367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330016J05; 4933411J24Rik
    Summary
    Predicted to enable methylated histone binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to histone methyltransferase activity (H3-K4 specific). Acts upstream of or within histone H3-K4 methylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Is expressed in cerebral cortex and genitourinary system. Orthologous to human RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.4), cerebellum adult (RPKM 6.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbbp5 in Genome Data Viewer
    Location:
    1 E4; 1 57.24 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132405087..132436382)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132477348..132505665)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57562 Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene RIKEN cDNA 6030442K20 gene Neighboring gene STARR-seq mESC enhancer starr_02257 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:134373585-134373776 Neighboring gene transmembrane protein 81 Neighboring gene contactin 2 Neighboring gene predicted gene, 51646

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Zhang P, et al. Genes Dev, 2015 Jan 15. PMID 25593305, Free PMC Article
    2. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Jiang H, et al. Cell, 2011 Feb 18. PMID 21335234, Free PMC Article
    3. Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1. Odho Z, et al. J Biol Chem, 2010 Oct 22. PMID 20716525, Free PMC Article
    4. Evolving Catalytic Properties of the MLL Family SET Domain. Zhang Y, et al. Structure, 2015 Oct 6. PMID 26320581, Free PMC Article
    5. Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Ang YS, et al. Cell, 2011 Apr 15. PMID 21477851, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a phosphorylation switch on RbBP5 stimulates WRAD complex formation and significantly increases KMT2 (lysine [K] methyltransferase 2) enzyme methylation rates
      Title: A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.
    2. Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1.
      Title: Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1/2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retinoblastoma-binding protein 5
    Names
    RBBP-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357486.1 → NP_001344415.1  retinoblastoma-binding protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107846
      UniProtKB/TrEMBL
      A0A0R4J2B6
      Conserved Domains (3) summary
      PTZ00441
      Location:340 → 493
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:29 → 64
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:30 → 322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001357487.1 → NP_001344416.1  retinoblastoma-binding protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107846
      Consensus CDS
      CCDS87875.1
      UniProtKB/TrEMBL
      A0A087WST2
      Related
      ENSMUSP00000027700.10, ENSMUST00000027700.15
      Conserved Domains (3) summary
      COG2319
      Location:10 → 194
      WD40; WD40 repeat [General function prediction only]
      PTZ00441
      Location:213 → 366
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:75 → 120
      7WD40; WD40 repeat [structural motif]

    3. NM_172517.2 → NP_766105.2  retinoblastoma-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_766105.2

      Status: VALIDATED

      Source sequence(s)
      AC107846, AK049247, BY193756, CV562303
      Consensus CDS
      CCDS15286.1
      UniProtKB/Swiss-Prot
      Q3TBL4, Q3U3G1, Q6PAP0, Q6PFC2, Q8BX09
      UniProtKB/TrEMBL
      A0A0R4J2B6
      Related
      ENSMUSP00000141003.2, ENSMUST00000190997.7
      Conserved Domains (3) summary
      PTZ00441
      Location:340 → 498
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:29 → 64
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:30 → 322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132405087..132436382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529358.4 → XP_006529421.1  retinoblastoma-binding protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0R4J2B6
      Conserved Domains (3) summary
      PTZ00441
      Location:301 → 459
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:30 → 67
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:34 → 283
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_030252808.2 → XP_030108668.1  retinoblastoma-binding protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0R4J2B6
      Conserved Domains (3) summary
      PTZ00441
      Location:301 → 454
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:30 → 67
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:34 → 283
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_036163427.1 → XP_036019320.1  retinoblastoma-binding protein 5 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:9 → 98
      WD40; WD40 repeat [General function prediction only]
      PTZ00441
      Location:99 → 257
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:16 → 50
      7WD40; WD40 repeat [structural motif]

    4. XM_036163429.1 → XP_036019322.1  retinoblastoma-binding protein 5 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:9 → 98
      WD40; WD40 repeat [General function prediction only]
      PTZ00441
      Location:99 → 257
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:16 → 50
      7WD40; WD40 repeat [structural motif]

    5. XM_036163434.1 → XP_036019327.1  retinoblastoma-binding protein 5 isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:9 → 80
      WD40; WD40 repeat [General function prediction only]
      PTZ00441
      Location:99 → 252
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00039
      Location:16 → 50
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_003954377.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX09.2 GenPept UniProtKB/Swiss-Prot:Q8BX09

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