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    Tln2 talin 2 [ Mus musculus (house mouse) ]

    Gene ID: 70549, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tln2provided by MGI
    Official Full Name
    talin 2provided by MGI
    Primary source
    MGI:MGI:1917799
    See related
    Ensembl:ENSMUSG00000052698 AllianceGenome:MGI:1917799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0320; 5730421P04Rik
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell-cell adhesion. Located in fascia adherens and synapse. Is expressed in several structures, including brain; ganglia; submandibular gland; trigeminal nerve; and vibrissa. Orthologous to human TLN2 (talin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 19.0), testis adult (RPKM 15.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 C; 9 36.39 cM
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (67124371..67541357, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (67217085..67634045, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24488 Neighboring gene predicted gene 10646 Neighboring gene predicted gene, 22145 Neighboring gene STARR-seq mESC enhancer starr_24489 Neighboring gene predicted gene, 19299 Neighboring gene predicted gene, 40529 Neighboring gene STARR-seq mESC enhancer starr_24490 Neighboring gene STARR-seq mESC enhancer starr_24492 Neighboring gene microRNA 190a Neighboring gene STARR-seq mESC enhancer starr_24494 Neighboring gene STARR-seq mESC enhancer starr_24495 Neighboring gene STARR-seq mESC enhancer starr_24496 Neighboring gene STARR-seq mESC enhancer starr_24498 Neighboring gene predicted gene, 30936 Neighboring gene C2 calcium-dependent domain containing 4B Neighboring gene microRNA 7241

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload. Noll NA, et al. Am J Physiol Heart Circ Physiol, 2022 May 1. PMID 35333120, Free PMC Article
    2. Talin-2 regulates integrin functions in exosomes. Soe ZY, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30879762
    3. Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms. Debrand E, et al. FEBS J, 2009 Mar. PMID 19220457, Free PMC Article
    4. The N-terminal half of talin2 is sufficient for mouse development and survival. Chen NT, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16202389
    5. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Austen K, et al. Nat Cell Biol, 2015 Dec. PMID 26523364, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload.
      Title: Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload.
    2. Talin-2-deficient T-cell exosomes were less efficiently internalized by endothelial cells, compared with control exosomes.
      Title: Talin-2 regulates integrin functions in exosomes.
    3. talin unfolding determines DLC1 downstream signalling and, consequently, cell mechanics.
      Title: Mechanotransduction in talin through the interaction of the R8 domain with DLC1.
    4. Loss of all Tln forms from the heart-muscle cell leads to myocyte instability and a dilated cardiomyopathy.
      Title: Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy.
    5. Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.
      Title: Vinculin controls talin engagement with the actomyosin machinery.
    6. Data indicate that talin mechanics are isoform specific so that expression of either talin-1 or talin-2 modulates extracellular rigidity sensing.
      Title: Extracellular rigidity sensing by talin isoform-specific mechanical linkages.
    7. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.
      Title: Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.
    8. Tln2(cd/cd) mice showed no major difference in body mass or the weight of the major organs compared to wild-type, although they displayed a mildly dystrophic phenotype.
      Title: Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.
    9. Talin1 was concentrated in peripheral focal adhesions while talin2 was observed in both focal and fibrillar adhesions, and knock-down of talin2 compromised fibronectin fibrillogenesis
      Title: New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
    10. Fxr1 knockout hearts exhibit an up-regulation of desmoplakin and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
      Title: Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC100340

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fascia adherens IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    talin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081242.3 → NP_001074711.2  talin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107740, AC173343, CT573422
      Consensus CDS
      CCDS52849.1
      UniProtKB/TrEMBL
      B2RY15, E9PUM4
      Related
      ENSMUSP00000039633.8, ENSMUST00000040025.14
      Conserved Domains (10) summary
      cd12150
      Location:1656 → 1827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90 → 316
      B41; Band 4.1 homologues
      smart00307
      Location:2337 → 2532
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312 → 403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206 → 316
      FERM_M; FERM central domain
      pfam08913
      Location:1850 → 1974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494 → 655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706 → 832
      I_LWEQ; I/LWEQ domain

    2. NM_001408298.1 → NP_001395227.1  talin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107740, AC173343, CT573422

    3. NM_001408299.1 → NP_001395228.1  talin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107740

    4. NM_001408300.1 → NP_001395229.1  talin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC107740

    5. NM_001408301.1 → NP_001395230.1  talin-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC107740

    6. NM_027458.2 → NP_081734.1  talin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107740
      UniProtKB/TrEMBL
      A0A1L1SRI1, Q8CDM9
      Related
      ENSMUSP00000149284.2, ENSMUST00000215267.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      67124371..67541357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511434.5 → XP_006511497.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_006511497.1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      cd17172
      Location:6 → 89
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90 → 201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211 → 318
      FERM_M; FERM central domain
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    2. XM_011242812.4 → XP_011241114.1  talin-2 isoform X3

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2299 → 2509
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1852 → 1936
      VBS; Vinculin Binding Site
      cd17172
      Location:6 → 89
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90 → 201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211 → 318
      FERM_M; FERM central domain
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    3. XM_036155280.1 → XP_036011173.1  talin-2 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SQ51, B2RY15
      Related
      ENSMUSP00000148901.2, ENSMUST00000215784.2
      Conserved Domains (9) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2339 → 2534
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      cd17172
      Location:6 → 89
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90 → 201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211 → 318
      FERM_M; FERM central domain
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    4. XM_036155278.1 → XP_036011171.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      cd17172
      Location:6 → 89
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90 → 201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211 → 318
      FERM_M; FERM central domain
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    5. XM_006511433.3 → XP_006511496.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_006511496.1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      cd17172
      Location:6 → 89
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90 → 201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211 → 318
      FERM_M; FERM central domain
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    6. XM_036155279.1 → XP_036011172.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      cd17172
      Location:6 → 89
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90 → 201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211 → 318
      FERM_M; FERM central domain
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    7. XM_011242811.3 → XP_011241113.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_011241113.1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      cd17172
      Location:6 → 89
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90 → 201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211 → 318
      FERM_M; FERM central domain
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    8. XM_030244583.1 → XP_030100443.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:1658 → 1829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:2339 → 2549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314 → 405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:1852 → 1976
      VBS; Vinculin Binding Site
      cd17172
      Location:6 → 89
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90 → 201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211 → 318
      FERM_M; FERM central domain
      pfam09141
      Location:496 → 657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691 → 767
      I_LWEQ; I/LWEQ domain

    9. XM_006511441.3 → XP_006511504.1  talin-2 isoform X5

      UniProtKB/TrEMBL
      A0A1L1SRI1
      Related
      ENSMUSP00000149474.2, ENSMUST00000217550.2
      Conserved Domains (3) summary
      cd12150
      Location:504 → 675
      talin-RS; rod-segment of the talin C-terminal domain
      pfam08913
      Location:698 → 822
      VBS; Vinculin Binding Site
      cl19756
      Location:1185 → 1395
      I_LWEQ; I/LWEQ domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q71LX4.3 GenPept UniProtKB/Swiss-Prot:Q71LX4

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