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    Pex11g peroxisomal biogenesis factor 11 gamma [ Mus musculus (house mouse) ]

    Gene ID: 69129, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pex11gprovided by MGI
    Official Full Name
    peroxisomal biogenesis factor 11 gammaprovided by MGI
    Primary source
    MGI:MGI:1920905
    See related
    Ensembl:ENSMUSG00000069633 AllianceGenome:MGI:1920905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pex11c; Pex11gamma; 1810022F11Rik; 1810049N02Rik
    Summary
    Predicted to be involved in peroxisome fission and regulation of peroxisome size. Predicted to be located in peroxisome. Predicted to be intrinsic component of peroxisomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in peroxisomal membrane. Orthologous to human PEX11G (peroxisomal biogenesis factor 11 gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 14.0), liver adult (RPKM 13.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 1.92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3507105..3517648, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3457105..3467648, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:3354554-3354663 Neighboring gene predicted gene, 30369 Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene STARR-seq mESC enhancer starr_20578 Neighboring gene predicted gene, 46029 Neighboring gene STARR-positive B cell enhancer ABC_E10487 Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene zinc finger protein 358 Neighboring gene mucolipin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation. Li X, et al. Mol Cell Biol, 2002 Dec. PMID 12417726, Free PMC Article
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of peroxisome size ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal membrane protein 11C
    Names
    PEX11-gamma
    peroxin-11C
    peroxisomal biogenesis factor 11c
    protein PEX11 homolog gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368376.1 → NP_001355305.1  peroxisomal membrane protein 11C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC169677

    2. NM_001368377.1 → NP_001355306.1  peroxisomal membrane protein 11C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC169677

    3. NM_001368378.1 → NP_001355307.1  peroxisomal membrane protein 11C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC169677

    4. NM_026951.3 → NP_081227.1  peroxisomal membrane protein 11C isoform 2

      See identical proteins and their annotated locations for NP_081227.1

      Status: VALIDATED

      Source sequence(s)
      AC169677
      Consensus CDS
      CCDS22061.1
      UniProtKB/Swiss-Prot
      Q6P6M5, Q9D8P0, Q9D8X4
      Related
      ENSMUSP00000004686.7, ENSMUST00000004686.13
      Conserved Domains (1) summary
      pfam05648
      Location:4 → 230
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)

    5. NM_028594.1 → NP_082870.1  peroxisomal membrane protein 11C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC169677
      Consensus CDS
      CCDS90364.1
      Related
      ENSMUSP00000106710.4, ENSMUST00000111081.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      3507105..3517648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6M5.2 GenPept UniProtKB/Swiss-Prot:Q6P6M5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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